2,3,11,12-bis(4-carboxy)benzo-18-crown-6 | 85953-90-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3,11,12-bis(4-carboxy)benzo-18-crown-6
• 英文别名: 6,7,9,10,17,18,20,21-Octahydrodibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecine-2,14-dicarboxylic acid；2,5,8,15,18,21-hexaoxatricyclo[20.4.0.09,14]hexacosa-1(22),9(14),10,12,23,25-hexaene-11,25-dicarboxylic acid
• CAS: 85953-90-8
• 化学式: C₂₂H₂₄O₁₀
• mdl: MFCD00068491
• 分子量: 448.427
• InChiKey: BFKSDRWCIVPRSO-UHFFFAOYSA-N

物化性质

• 沸点：
  673.1±55.0 °C(Predicted)
• 密度：
  1.280±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  2,3,11,12-bis(4-carboxy)benzo-18-crown-6 在 吡啶 、 氯化亚砜 作用下， 以 苯 为溶剂， 反应 6.0h， 生成 11-[[25-(10-Carboxydecylcarbamoyl)-2,5,8,15,18,21-hexaoxatricyclo[20.4.0.09,14]hexacosa-1(22),9(14),10,12,23,25-hexaene-11-carbonyl]amino]undecanoic acid
  参考文献：
  名称：

  New Macrocyclic Derivatives Containing Chiral and Linear Lateral Amino-Acid Moieties

  摘要：

  We report the preparation of a new series of functionalized derivatives of dibenzo-18-crown-6, containing in second sphere of coordination lateral arms of different Linear and chiral L-amino acids: glycine, beta-alanine, 11-aminoundecanoic acid, L-cysteine, L-aspartic acid, L-phenylalanine, L-tryptophan, L-histidine. All these new derivatives were characterized by elemental analysis, LR and H-1-NMR spectroscopy, and these data were in agreement with proposed molecular structures.

  DOI：

  10.1002/(sici)1099-0690(199808)1998:8<1705::aid-ejoc1705>3.0.co;2-j
• 作为产物：
  描述：

  二苯并-18-冠醚-6 、 溶剂黄146 在 偏磷酸 、 溴 、 sodium hydroxide 作用下， 生成 2,3,11,12-bis<4(5')-carboxy>benzo-18-crown-6 、 2,3,11,12-bis(4-carboxy)benzo-18-crown-6
  参考文献：
  名称：

  Razus, Alexandru C.; Birzan, Liviu; Tecuceanu, Victorita, Revue Roumaine de Chimie, 2011, vol. 56, # 4, p. 335 - 339

  摘要：

  DOI：

文献信息

• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS
  申请人：Chodorowski-Kimmes Sandrine

  公开号：US20100239509A1

  公开（公告）日：2010-09-23

  The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups; of a monocarboxylic acid containing 6 to 32 carbon atoms; of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and (b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

  本专利申请涉及一种化妆品或皮肤科学组合物，包括在化妆品或皮肤科学上可接受的介质中，包含以下聚合物的组合物：(a) 由以下反应得到的聚合物骨架：含有3至6个羟基的多元醇；含有6至32个碳原子的一元羧酸；至少含有两个羧基COOH的多元羧酸，和/或类似多元羧酸的环酐和/或至少含有一个羧基COOH的内酯；以及(b) 至少一个连接到所述聚合物骨架的连接基团，并能够与一个或多个配对连接基团建立H键，每个连接基团的配对涉及至少三个H（氢）键。该专利申请还涉及使用所述组合物的化妆品处理过程。
• COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION
  申请人：GIUSTINIANI Pascal

  公开号：US20090028807A1

  公开（公告）日：2009-01-29

  The present application relates to a cosmetic or pharmaceutical, in particular lipstick, composition comprising a polycondensate The application also relates to a method of cosmetic treatment using the composition, the polycondensate thus defined and a method of preparing the polycondensate.

  本申请涉及一种化妆品或药用品，特别是口红，包括聚缩酸酯的组合物。该申请还涉及一种使用该组合物进行化妆处理的方法，所述聚缩酸酯的定义以及一种制备聚缩酸酯的方法。
• COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT
  申请人：Malle Gerard

  公开号：US20100272660A1

  公开（公告）日：2010-10-28

  The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

  本申请涉及一种化妆品或药用组合物，包括由以下单体反应而得的聚缩酸酯：相对于聚缩酸酯的总重量，占10至30%的一种或多种含有3至6个羟基的多元醇；占30至80%的一种或多种线性、支链和/或环状、饱和或不饱和、非芳香族的单羧酸，含有6至32个碳原子；占聚缩酸酯总重量的1至40%的一种或多种多羧酸和/或多羧酸的环状酐和/或含有至少一个COOH基团的内酯；以及可选地占聚缩酸酯总重量的0.1至15%的一种或多种硅氧烷，具有羟基和/或羧基官能团。该申请还涉及使用所述组合物进行化妆处理的方法，以及如此定义的聚缩酸酯。
• LOKTEV, V. F.;MOROZOVA, I. YU.;TASHMUXAMEDOVA, A. K., IZV. VUZOV. XIMIYA I XIM. TEXNOL., 32,(1989) N, S. 119-120
  作者：LOKTEV, V. F.、MOROZOVA, I. YU.、TASHMUXAMEDOVA, A. K.

  DOI：——

  日期：——
• US8968711B2
  申请人：——

  公开号：US8968711B2

  公开（公告）日：2015-03-03