2,2-diphenyl-5-hydroxy-6-carboethoxy-2H-naphtho[1,2-b]pyran | 402564-10-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2,2-diphenyl-5-hydroxy-6-carboethoxy-2H-naphtho[1,2-b]pyran
• 英文别名: Ethyl 5-hydroxy-2,2-diphenylbenzo[h]chromene-6-carboxylate
• CAS: 402564-10-7
• 化学式: C₂₈H₂₂O₄
• 分子量: 422.48
• InChiKey: WQVGLMPIAZHCHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  595.9±50.0 °C(Predicted)
• 密度：
  1.263±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  吗啉 、 2,2-diphenyl-5-hydroxy-6-carboethoxy-2H-naphtho[1,2-b]pyran 在 乙基氯化镁 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 3.0h， 生成 2,2-diphenyl-5-hydroxy-6-morpholinocarbonyl-2H-naphtho[1,2-b]pyran
  参考文献：
  名称：

  Photochromic naphthopyrans

  摘要：

  描述了具有萘并［1,2-b］吡喃环2位具有特定取代基，5位和6位以及化合物的萘部分的7、8、9和10位位置可选地具有特定取代基的新型光致变色萘［1,2-b］吡喃化合物。这些化合物可以用以下图式表示： 还描述了含有或涂有这些化合物的聚合有机宿主材料。还描述了包含新型萘吡喃化合物或其与互补光致变色化合物（例如，某些其他萘吡喃、苯并吡喃和螺(indoline)型化合物）的组合的光学透明物品，例如眼镜或隐形眼镜。

  公开号：

  US06353102B1
• 作为产物：
  描述：

  2,4-dihydroxy-[1]naphthoic acid ethyl ester 、 1,1-二苯基-2-丙炔-1-醇 在 对甲苯磺酸 作用下， 以 氯仿 为溶剂， 反应 8.0h， 生成 2,2-diphenyl-5-hydroxy-6-carboethoxy-2H-naphtho[1,2-b]pyran
  参考文献：
  名称：

  Photochromic naphthopyrans

  摘要：

  描述了具有萘并［1,2-b］吡喃环2位具有特定取代基，5位和6位以及化合物的萘部分的7、8、9和10位位置可选地具有特定取代基的新型光致变色萘［1,2-b］吡喃化合物。这些化合物可以用以下图式表示： 还描述了含有或涂有这些化合物的聚合有机宿主材料。还描述了包含新型萘吡喃化合物或其与互补光致变色化合物（例如，某些其他萘吡喃、苯并吡喃和螺(indoline)型化合物）的组合的光学透明物品，例如眼镜或隐形眼镜。

  公开号：

  US06353102B1

文献信息

• Photochromic blue light filtering materials and ophthalmic devices
  申请人：Jani M. Dharmendra

  公开号：US20050254003A1

  公开（公告）日：2005-11-17

  Polymeric compositions have photochromic and blue-light filtering ability and are useful in the manufacture of ophthalmic medical devices. The polymeric compositions comprise a photochromic material incorporated into polymeric host materials and are activatable by blue light having a first wavelength range to become photochromic, and are thereby capable of absorbing blue light in a second wavelength range. Methods of making the compositions comprise incorporating a photochromic material into a polymeric host material.

  聚合物组合物具有光致变色和蓝光过滤能力，并可用于制造眼科医疗器械。该聚合物组合物包括将光致变色材料并入聚合物基材料中，可以通过第一波长范围的蓝光激活变成光致变色，并且因此能够吸收第二波长范围的蓝光。制造该组合物的方法包括将光致变色材料并入聚合物基材料中。
• PHOTOCHROMIC BLUE LIGHT FILTERING MATERIALS AND OPHTHALMIC DEVICES
  申请人：BAUSCH & LOMB INCORPORATED

  公开号：EP1877856A1

  公开（公告）日：2008-01-16
• PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS
  申请人：Alcon Inc.

  公开号：US20210284806A1

  公开（公告）日：2021-09-16

  The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a photochromic contact lens from a polymerizable composition comprising at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.
• METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES
  申请人：Alcon Inc.

  公开号：US20210371731A1

  公开（公告）日：2021-12-02

  Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).
• METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES
  申请人：Alcon Inc.

  公开号：US20220281193A1

  公开（公告）日：2022-09-08

  Described herein is a method for producing a contact lens comprising a central zone that has a diameter of about 13 mm or less, is concentric with the central axis of the contact lens, and possesses at least one photo functionality. The method comprises: applying a first polymerizable fluid composition containing at least one photochemically functional compound on a central portion of the molding surface of a female mold half to form a circular layer; partially curing, in situ, the circular layer in the female mold half; dispensing a second polymerizable fluid composition over the partially-cured circular layer on the molding surface of the female mold half; and a step of curing the second polymerizable fluid composition and the partially-cured circular layer immersed therein in the mold cavity formed between the the molding surfaces of the female mold half and a male mold half.