3-phenanthroyl-trifluoroacetone | 95780-08-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-phenanthroyl-trifluoroacetone
• 英文别名: 4,4,4-Trifluoro-1-(3-phenanthryl)-1,3-butanedione；4,4,4-trifluoro-1-phenanthren-3-ylbutane-1,3-dione
• CAS: 95780-08-8
• 化学式: C₁₈H₁₁F₃O₂
• 分子量: 316.279
• InChiKey: QGZSAXCCIIHFMM-UHFFFAOYSA-N

物化性质

• 沸点：
  444.3±40.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  哌啶 、 3-phenanthroyl-trifluoroacetone 、 氯化铕(III) 以 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  氟化β-二酮衍生的荧光euro螯合物

  摘要：

  十四铕螯合物盐：哌啶+ [（RCOCHCOCF 3）4的Eu] - ，其中R是有机芳香分组，已经制备。所有的化合物，无论是固体形式还是在乙腈溶液中，都表现出强的室温Eu 3+橙红色荧光特征当用紫外线照射时。固体的室温荧光强度在化合物之间显着变化。发现固态的荧光强度主要取决于结合的euro原子的局部对称条件，而不是取决于与基团R与螯合环的共振和感应相互作用有关的电子效应。还描述了固体化合物的热性质，以及几种新的β-二酮的制备。

  DOI：

  10.1016/0022-1902(67)80328-2
• 作为产物：
  描述：

  三氟乙酸乙酯 、 3-乙酰基菲 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 3-phenanthroyl-trifluoroacetone
  参考文献：
  名称：

  Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus

  摘要：

  Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to public health because of its resistance to multiple antibiotics most commonly used to treat infection. In this study, we report the unique ability of the cyclooxygenase-2 (COX-2) inhibitor celecoxib to kill Staphylococcus aureus and MRSA with modest potency. We hypothesize that the anti-Staphylococcus activity of celecoxib could be pharmacologically exploited to develop novel anti-MRSA agents with a distinct mechanism. Examination of an in-house, celecoxib-based focused compound library in conjunction with structural modifications led to the identification of compound 46 as the lead agent with high antibacterial potency against a panel of Staphylococcus pathogens and different strains of MRSA. Moreover, this killing effect is bacteria-specific, as human cancer cells are resistant to 46. In addition, a single intraperitoneal administration of compound 46 at 30 mg/kg improved the survival of MRSA-infected C57BL/6 mice. In light of its high potency in eradicating MRSA in vitro and its in vivo activity, compound 46 and its analogues warrant continued preclinical development as a potential therapeutic intervention against MRSA. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.06.018

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Sc: MVol.D3, 5.1.14.3, page 190 - 192
  作者：

  DOI：——

  日期：——
• MODIFIKATION VON SCHICHTSILIKATEN FÜR DIE LUMINESZENZAKTIVIERUNG
  申请人：Inbio Prof. Jürgen Büddefeld Dr. Peter Klauth Prof. Manfred Rietz Gbr

  公开号：EP2417216A2

  公开（公告）日：2012-02-15
• Light emitting device and lighting device using it, image display unit
  申请人：Yabe Akiko

  公开号：US20070132366A1

  公开（公告）日：2007-06-14

  An object of the present invention is to provide a light emitting device which is high in emission intensity and stable, that is to say, a light emitting device in which when an LED or LD having an emission peak at 380 nm to 410 nm is used as an excitation light source of the light emitting device, the emission intensity of a red phosphor does not largely change to some deviation of the emission wavelength of the LED or LD to maintain not only brightness but also a balance at the time when mixed with a blue and green phosphors. The present invention relates to a light emitting device characterized in that the device comprises a phosphor which has Eu 3+ as a luminescent center ion, in which a minimum emission intensity within the excitation wavelength range of 380 nm to 410 nm in an excitation spectrum is 65% or more of a maximum emission intensity, and which has an emission efficiency at 400 nm of 20% or more, and a semiconductor light emitting element which emits light in the region from near-ultraviolet light to visible light.
• [DE] MODIFIKATION VON SCHICHTSILIKATEN FÜR DIE LUMINESZENZAKTIVIERUNG<br/>[EN] MODIFICATION OF LAYERED SILICATES FOR LUMINESCENCE ACTIVATION<br/>[FR] MODIFICATION DE PHYLLOSILICATES POUR ACTIVATION DE LUMINESCENCE
  申请人：INBIO PROF JUERGEN BUEDDEFELD

  公开号：WO2010115503A2

  公开（公告）日：2010-10-14

  Die Erfindung betrifft ein Verfahren zur Herstellung eines lumineszenzfähigen Schichtsilikatverbundes. Das erfindungsgemässe Verfahren zeichnet sich dadurch aus, dass mindestens ein Lumineszenzfarbstoff, insbesondere Fluoreszenfarbstoff, auf Basis mindestens eines Komplexes, insbesondere Chelatkomplexes, mindestens eines Elements der Seltenen Erden ("Seltenerdkomplex") zwischen mindestens zwei Lagen jeweils mindestens eines Schichtsilikates ("Schichtsilikatlagen") eingebracht und/oder eingelagert wird bzw. dass mindestens ein Lumineszenzfarbstoff, insbesondere Fluoreszenzfarbstoff, auf Basis mindestens eines Komplexes, insbesondere Chelatkomplexes, mindestens eines Elements der Seltenen Erden ("Seltenerdkomplex") mit einem Schichtsilikat zu einem Verbund zusammengeführt wird. Der erfindungsgemässe lumineszenzfähige Schichtsilikatverbund kann zur Markierung von Gegenständen, beispielsweise auf Kunststoffbasis, oder im Bereich der Bioanalytik eingesetzt werden.
• [EN] COMPOUND OR MIXTURE OF PHOTOLUMINESCENT COMPOUNDS<br/>[FR] COMPOSÉ OU MÉLANGE DE COMPOSÉS PHOTOLUMINESCENTS
  申请人：ENI SPA

  公开号：WO2012065981A1

  公开（公告）日：2012-05-24

  Compound comprising a metal belonging to the family of lanthanides or mixture of compounds comprising a metal belonging to the family of lanthanides. Both said compound and said mixture of compounds,can be advantageously used in the construction of spectrum converters capable of enhancing the performances of solar devices (i.e. devices for the utilizationof solar energy) such as, for example, photovoltaic cells, photoelectrolytic cells.

表征谱图