1-methoxy-but-3-yn-2-ol | 50561-10-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-methoxy-but-3-yn-2-ol
• 英文别名: 1-Methoxy-but-3-in-2-ol；1-Methoxy-3-butyn-2-ol；1-methoxybut-3-yn-2-ol
• CAS: 50561-10-9
• 化学式: C₅H₈O₂
• 分子量: 100.117
• InChiKey: MECYGCRDPKFXFH-UHFFFAOYSA-N

物化性质

• 沸点：
  160.7±25.0 °C(Predicted)
• 密度：
  1.010±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ethyl propiolate 在 锂硼氢 作用下， 以 甲基叔丁基醚 为溶剂， 以1.5 g的产率得到1-methoxy-but-3-yn-2-ol
  参考文献：
  名称：

  [EN] SMALL MOLECULE MODULATORS OF IL-17
  [FR] MODULATEURS À PETITES MOLÉCULES D'IL-17

  摘要：

  The present invention relates to a compound according to formula (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

  公开号：

  WO2023166172A1

文献信息

• Adams et al., Journal of the Chemical Society, 1959, p. 559,565
  作者：Adams et al.

  DOI：——

  日期：——
• [EN] SMALL MOLECULE MODULATORS OF IL-17<br/>[FR] MODULATEURS À PETITES MOLÉCULES D'IL-17
  申请人：[en]LEO PHARMA A/S

  公开号：WO2023166172A1

  公开（公告）日：2023-09-07

  The present invention relates to a compound according to formula (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.