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3-(4-甲基哌啶-1-基)-1-苯基丙烷-1-酮 | 6622-90-8

中文名称
3-(4-甲基哌啶-1-基)-1-苯基丙烷-1-酮
中文别名
——
英文名称
Phenyl-β-<4-pipecolino>-ethyl-keton
英文别名
3-(4-methyl-piperidin-1-yl)-1-phenyl-propan-1-one;3-(4-Methylpiperidin-1-yl)-1-phenylpropan-1-one
3-(4-甲基哌啶-1-基)-1-苯基丙烷-1-酮化学式
CAS
6622-90-8
化学式
C15H21NO
mdl
——
分子量
231.338
InChiKey
LVTXFVGIXHOMSX-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    352.7±25.0 °C(Predicted)
  • 密度:
    1.001±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    2.9
  • 重原子数:
    17
  • 可旋转键数:
    4
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.53
  • 拓扑面积:
    20.3
  • 氢给体数:
    0
  • 氢受体数:
    2

SDS

SDS:13a768901b21dcf251885ac3850bd0e6
查看

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    参考文献:
    名称:
    具有苄基的羟氨基化合物的电氧化环化
    摘要:
    摘要 通过在甲醇中使用电氧化法,分别从N-苄基-2-哌啶甲醇和N-苄基-2-哌啶甲醇合成了几种新颖的2-芳基-1,3-恶嗪烷和2-芳基-1,3-恶唑烷衍生物。对于这些反应,通过使用催化量的碘离子显着提高了相应环化化合物的产率。相反,3-二烷基氨基-1-苯基丙醇仅使用少量过量的碱即可得到预期的环状6-苯基-1,3-恶嗪烷衍生物。 通过在甲醇中使用电氧化法,分别从N-苄基-2-哌啶甲醇和N-苄基-2-哌啶甲醇合成了几种新颖的2-芳基-1,3-恶嗪烷和2-芳基-1,3-恶唑烷衍生物。对于这些反应,通过使用催化量的碘离子显着提高了相应环化化合物的产率。相反,3-二烷基氨基-1-苯基丙醇仅使用少量过量的碱即可得到预期的环状6-苯基-1,3-恶嗪烷衍生物。
    DOI:
    10.1055/s-0031-1290755
  • 作为产物:
    描述:
    4-甲基哌啶盐酸 作用下, 以 乙醇 为溶剂, 反应 14.0h, 生成 3-(4-甲基哌啶-1-基)-1-苯基丙烷-1-酮
    参考文献:
    名称:
    Hypolipidemic effects of α, β, and γ-alkylaminophenone analogs in rodents
    摘要:
    A number of N-substituted beta-alkylaminophenone derivatives including two alpha- and two gamma-alkylaminophenone analogs were synthesized and investigated for hypolipidemic activity in mice at 8 mg/kg/day ip. Most of these analogs were found to be significantly more active than lovastatin and clofibrate. N-Phenylpiperazinopropiophenone 16 was one of the best derivatives, lowering serum cholesterol levels 41% and serum triglyceride levels 48% after 16 days of drug administration in CF1 mice. In Sprague-Dawley rats, N-phenylpiperazinopropiophenone at 8 mg/kg/day orally also demonstrated more potent hypolipidemic activity than clofibrate, gemfibrozil, and lovastatin at their therapeutic dosage. It significantly reduced tissue cholesterol and triglyceride levels in the aorta wall tissue and lowered the cholesterol and triglyceride levels in chylomicron, very low density lipid (VLDL) and low density lipid (LDL) fractions, while it significantly elevated the cholesterol levels in high density lipid (HDL) fraction. This compound also proved to be active in lowering both cholesterol and triglyceride levels in hyperlipidemic mice and rats induced with atherogenic diet. In vitro liver acetyl coenzyme A (CoA) synthetase, 3-hydroxy-3-methyl glutaryl (HMG) CoA reductase, acyl CoA cholesterol acyl transferase (ACAT), sn-glycerol-3-phosphate acyltransferase, phosphatidylate phosphohydrolase, and hepatic lipoprotein lipase activities were significantly inhibited by N-phenylpiperazinopropiophenone from 25 to 100 mu M.
    DOI:
    10.1016/0223-5234(96)80365-5
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文献信息

  • Hypolipidemic effects of α, β, and γ-alkylaminophenone analogs in rodents
    作者:Y Huang、IH Hall
    DOI:10.1016/0223-5234(96)80365-5
    日期:1996.1
    A number of N-substituted beta-alkylaminophenone derivatives including two alpha- and two gamma-alkylaminophenone analogs were synthesized and investigated for hypolipidemic activity in mice at 8 mg/kg/day ip. Most of these analogs were found to be significantly more active than lovastatin and clofibrate. N-Phenylpiperazinopropiophenone 16 was one of the best derivatives, lowering serum cholesterol levels 41% and serum triglyceride levels 48% after 16 days of drug administration in CF1 mice. In Sprague-Dawley rats, N-phenylpiperazinopropiophenone at 8 mg/kg/day orally also demonstrated more potent hypolipidemic activity than clofibrate, gemfibrozil, and lovastatin at their therapeutic dosage. It significantly reduced tissue cholesterol and triglyceride levels in the aorta wall tissue and lowered the cholesterol and triglyceride levels in chylomicron, very low density lipid (VLDL) and low density lipid (LDL) fractions, while it significantly elevated the cholesterol levels in high density lipid (HDL) fraction. This compound also proved to be active in lowering both cholesterol and triglyceride levels in hyperlipidemic mice and rats induced with atherogenic diet. In vitro liver acetyl coenzyme A (CoA) synthetase, 3-hydroxy-3-methyl glutaryl (HMG) CoA reductase, acyl CoA cholesterol acyl transferase (ACAT), sn-glycerol-3-phosphate acyltransferase, phosphatidylate phosphohydrolase, and hepatic lipoprotein lipase activities were significantly inhibited by N-phenylpiperazinopropiophenone from 25 to 100 mu M.
  • Electrooxidative Cyclization of Hydroxyamino Compounds Possessing a Benzyl Group
    作者:Mitsuhiro Okimoto、Kousuke Ohashi、Haruki Yamamori、Shinnosuke Nishikawa、Masayuki Hoshi、Takashi Yoshida
    DOI:10.1055/s-0031-1290755
    日期:2012.5
    3-oxazinane derivatives using only a small excess of base. Several novel 2-aryl-1,3-oxazinane and 2-aryl-1,3-oxazolidine derivatives were synthesized from N-benzyl-2-piperidineethanols and N-benzyl-2-piperidinemethanols, respectively, by using electrooxidative methods in methanol. For these reactions, the yields of the corresponding cyclized compounds were significantly increased by using catalytic amounts
    摘要 通过在甲醇中使用电氧化法,分别从N-苄基-2-哌啶甲醇和N-苄基-2-哌啶甲醇合成了几种新颖的2-芳基-1,3-恶嗪烷和2-芳基-1,3-恶唑烷衍生物。对于这些反应,通过使用催化量的碘离子显着提高了相应环化化合物的产率。相反,3-二烷基氨基-1-苯基丙醇仅使用少量过量的碱即可得到预期的环状6-苯基-1,3-恶嗪烷衍生物。 通过在甲醇中使用电氧化法,分别从N-苄基-2-哌啶甲醇和N-苄基-2-哌啶甲醇合成了几种新颖的2-芳基-1,3-恶嗪烷和2-芳基-1,3-恶唑烷衍生物。对于这些反应,通过使用催化量的碘离子显着提高了相应环化化合物的产率。相反,3-二烷基氨基-1-苯基丙醇仅使用少量过量的碱即可得到预期的环状6-苯基-1,3-恶嗪烷衍生物。
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