5-acetyl-2-dimethylamino-4-methylthiazole | 58350-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-acetyl-2-dimethylamino-4-methylthiazole
• 英文别名: 1-(2-dimethylamino-4-methyl-thiazol-5-yl)-ethanone；5-Acetyl-2-dimethylamino-4-methylthiazol；1-[2-(dimethylamino)-4-methyl-1,3-thiazol-5-yl]ethanone
• CAS: 58350-43-9
• 化学式: C₈H₁₂N₂OS
• mdl: MFCD16664651
• 分子量: 184.262
• InChiKey: HUYNGJGYJOAURE-UHFFFAOYSA-N

物化性质

• 熔点：
  64.0-65.5 °C(Solv: ligroine (8032-32-4))
• 沸点：
  278.0±32.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酰丙酮 在 溴 作用下， 以 四氯化碳 、 水 、 丙酮 为溶剂， 反应 45.5h， 生成 5-acetyl-2-dimethylamino-4-methylthiazole
  参考文献：
  名称：

  Caldwell, Jennifer M.; Meakins, G. Denis; Jones, Richard H., Journal of the Chemical Society. Perkin transactions I, 1987, p. 2305 - 2310

  摘要：

  DOI：

文献信息

• BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
  申请人：JACKSON Paul Francis

  公开号：US20120129842A1

  公开（公告）日：2012-05-24

  This invention relates to bisthiazole I and its therapeutic and prophylactic uses, wherein the variables A, R 5 , R 6 , and R 7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.

  本发明涉及双噻唑I及其治疗和预防用途，其中变量A，R 5 ，R 6 ，和R 7 在说明书中定义。治疗的和/或预防的疾病包括类风湿性关节炎。
• Studies of heterocyclic compounds. V. Synthesis of 5,6-dihydrothiazolo(2,3-b)thiazolium salts and their reactions with amines. A new synthesis of 2-aminothiazoles.
  作者：HIROKO OHTSUKA、HATSUNORI TOYOFUKU、TADASHI MIYASAKA、KIICHI ARAKAWA

  DOI：10.1248/cpb.23.3234

  日期：——

  5, 6-Dihydrothiazolo [2, 3-b] thiazolium salts (1a-d) were synthesized from 2-mercapto-thiazoline and α-haloketones. The reaction of 1 with a secondary amine gave 2-aminothiazole (7a-1) with the liberation of thiirane (9) via an unstable adduct, 7a-amino-2, 3, 5, 6-tetrahydrothiazolo [2, 3-b] thiazole (8a-g). The reaction of 1 with a primary amine afforded 3-(2-mercaptoethyl)-4-thiazolin-2-imine (10) and/or its disulfide (11). The reaction of 1 with an amine was concluded to be initiated by the attack of the reagent on C-7a.

  5, 6-二氢噻唑 [2, 3-b] 噻唑鎓盐（1a-d）是通过2-巯基噻唑啉和α-卤酮合成的。1与二级胺的反应生成了2-氨基噻唑（7a-1），同时通过不稳定的加合物7a-氨基-2, 3, 5, 6-四氢噻唑 [2, 3-b] 噻唑（8a-g）释放出噻烷（9）。1与一级胺的反应产生了3-(2-巯基乙基)-4-噻唑啉-2-亚胺（10）和/或其二硫化物（11）。关于1与胺的反应，结论是反应的起始是由于试剂对C-7a的攻击。
• [EN] N-(4-(4-METHYLTHIAZOL-5-YL) PYRIMIDIN-2-YL) -N-PHENYLAMINES AS ANTIPROLIFERATIVE COMPOUNDS<br/>[FR] N-(4-(4-METHYLTHIAZOL-5-YL) PYRIMIDINE-2-YL) -N-PHENYLAMINES COMME COMPOSES A ACTION ANTIPROLIFERANTE
  申请人：CYCLACEL LTD

  公开号：WO2003029248A1

  公开（公告）日：2003-04-10

  The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.

  本发明涉及2-取代的4-杂环芳基嘧啶，它们的制备，包含它们的药物组合物以及它们作为细胞周期依赖性激酶（CDKs）的抑制剂的用途，因此可用于治疗增生性疾病，如癌症、白血病、牛皮癣等。
• N-(4-(4-methylthiazol-5-yl)pyrimidin-2-yl)-N-phenylamines as antiproliferative compounds
  申请人：——

  公开号：US20040259894A1

  公开（公告）日：2004-12-23

  The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukemia, psoriasis and the like.

  本发明涉及2-取代的4-杂环芳基嘧啶、它们的制备、含有它们的药物组合物以及它们作为细胞周期蛋白依赖性激酶（CDKs）的抑制剂的用途，因此可用于治疗增殖性疾病，如癌症、白血病、牛皮癣等。
• Anti-viral compounds
  申请人：Wang Shudong

  公开号：US20050288307A1

  公开（公告）日：2005-12-29

  The present invention relates to the use of 2-substituted 4-heteroaryl-pyrimidines and related compounds in the treatment of viral disorders.

  本发明涉及使用2-取代的4-杂环基嘧啶和相关化合物治疗病毒性疾病。