ines were synthesized starting from 2-cyano-8-hydroxyquinoline. These N,N,P-chelates were successfully employed in the Ru(II)-catalyzed asymmetric cyclopropanation reactions of diazo-alkenes. The catalytic system exhibited good reactivity and high thermal stability and provided high yields in the intramolecular cyclopropanation, albeit somewhat decreased enantioselectivities compared to known catalytic
从2-
氰基-
8-羟基喹啉开始合成了几种手性的8-
二苯基膦基-2-
恶唑啉基
喹啉。这些N,N,P螯合物已成功用于Ru(II)催化的重氮烯烃的不对称
环丙烷化反应中。该催化体系表现出良好的反应性和高热稳定性,并且在分子内
环丙烷化中提供了高产率,尽管与已知的催化体系相比,对映选择性有所降低。观察到对映选择性对
恶唑啉环的取代基的显着依赖性。