3-(8-羟基喹啉-2-基)丙-2-烯酸 | 91493-45-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3-(8-羟基喹啉-2-基)丙-2-烯酸
• 英文名称: (E)-3-(8-hydroxyquinolin-2-yl)acrylic acid
• 英文别名: 3t-(8-hydroxy-[2]quinolyl)-acrylic acid；3t-(8-Hydroxy-[2]chinolyl)-acrylsaeure；3-(8-Hydroxy-quinolin-2-YL)-acrylic acid；(E)-3-(8-hydroxyquinolin-2-yl)prop-2-enoic acid
• CAS: 91493-45-7
• 化学式: C₁₂H₉NO₃
• 分子量: 215.208
• InChiKey: IUVXVLBCPIBXLZ-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(8-羟基喹啉-2-基)丙-2-烯酸 在 盐酸 、 乙醇 作用下， 生成 ethyl (E)-3-(8-hydroxyquinolin-2-yl)acrylate
  参考文献：
  名称：

  Donor finger morbidity in cross-finger flaps

  摘要：

  We reviewed 16 patients who had cross-finger flap procedures carried out between 1991 and 1996 at the West Midlands Regional centre for Plastic and Reconstructive Surgery. We looked specifically at the donor finger morbidity of each patient with a median follow up interval of 43 months.At follow up there were 10 patients with cold intolerance, eight patients with subjective joint stiffness and a documented reduced range of finger joint movement. Skin graft reconstruction of the secondary defect was associated with poor colour match in eight cases (seven hyperpigmented, one hypopigmented) and visible contour deformity in eight cases. There were no clinically significant differences between split skin graft or full thickness skin graft for donor finger reconstruction.Although cross-finger flaps may provide soft tissue cover in a variety of finger pulp injuries, these results show an alarming incidence of donor finger morbidity associated with such procedures. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0020-1383(99)00205-3
• 作为产物：
  描述：

  ethyl (E)-3-(8-hydroxyquinolin-2-yl)acrylate 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以85%的产率得到3-(8-羟基喹啉-2-基)丙-2-烯酸
  参考文献：
  名称：

  Nitric oxide-donating and reactive oxygen species-responsive prochelators based on 8-hydroxyquinoline as anticancer agents

  摘要：

  DOI：

  10.1016/j.ejmech.2021.113153

文献信息

• [EN] QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA<br/>[FR] DÉRIVÉS DE QUINOLINE ET APPLICATIONS ASSOCIÉES DANS LA RHINITE ET L'URTICAIRE
  申请人：GLAXO GROUP LTD

  公开号：WO2010094643A1

  公开（公告）日：2010-08-26

  The present invention relates to compounds of formula (I) and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.

  本发明涉及式(I)的化合物及其盐，其制备方法，含有它们的组合物，以及它们在治疗各种疾病（如过敏性鼻炎）中的用途。
• Histamine Receptor Antagonists Comprising an Azepin Core
  申请人：Ancliff Rachael Ann

  公开号：US20090181950A1

  公开（公告）日：2009-07-16

  The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.

  本发明涉及式(I)的化合物及其盐，其制备过程，包含它们的组合物，以及它们在治疗各种疾病，如过敏性鼻炎中的应用。
• HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE
  申请人：Glaxo Group Limited

  公开号：EP2027108A1

  公开（公告）日：2009-02-25
• [EN] HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE<br/>[FR] ANTAGONISTES DE RÉCEPTEUR D'HISTAMINE COMPRENANT UN NOYAU D'AZEPINE
  申请人：GLAXO GROUP LTD

  公开号：WO2007135081A1

  公开（公告）日：2007-11-29

  [EN] The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.
  [FR] La présente invention concerne des composés de formule (I), et leurs sels, des procédés pour leur préparation, des compositions contenant ces composés et leur utilisation dans le traitement de différents troubles, comme la rhinite allergique.
• Nitric oxide-donating and reactive oxygen species-responsive prochelators based on 8-hydroxyquinoline as anticancer agents
  作者：Yuxia Zhang、Jiaxin Yang、Tingting Meng、Yajuan Qin、Tingyou Li、Junjie Fu、Jian Yin

  DOI：10.1016/j.ejmech.2021.113153

  日期：2021.2