4-bromo-3-ethoxy-3-methylbutane-1-ol | 1529781-47-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-bromo-3-ethoxy-3-methylbutane-1-ol
• 英文别名: 4-Bromo-3-ethoxy-3-methylbutan-1-ol；4-bromo-3-ethoxy-3-methylbutan-1-ol
• CAS: 1529781-47-2
• 化学式: C₇H₁₅BrO₂
• 分子量: 211.099
• InChiKey: QACSSVJCTXVPPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-甲基-3-丁烯-1-醇 、 乙醇 在 Oxone 、 溴化铵 作用下， 反应 2.3h， 以63%的产率得到4-bromo-3-ethoxy-3-methylbutane-1-ol
  参考文献：
  名称：

  Alkoxybromination of Olefins Using Ammonium Bromide and Oxone

  摘要：

  A mild, efficient, and highly regio- and stereoselective method for the methoxy and ethoxy bromination of olefins has been developed using NH4Br as a bromine source and Oxone as an oxidant. Various kinds of olefins (aromatic, linear, and cyclic olefins) afforded the corresponding alkoxy brominated products in moderate to excellent yields. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resources: Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2012.761238

文献信息

• Alkoxybromination of Olefins Using Ammonium Bromide and Oxone
  作者：Macharla Arun Kumar、Mameda Naresh、Chozhiyath Nappunni Rohitha、Nama Narender

  DOI：10.1080/00397911.2012.761238

  日期：2013.12.2

  A mild, efficient, and highly regio- and stereoselective method for the methoxy and ethoxy bromination of olefins has been developed using NH4Br as a bromine source and Oxone as an oxidant. Various kinds of olefins (aromatic, linear, and cyclic olefins) afforded the corresponding alkoxy brominated products in moderate to excellent yields. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resources: Full experimental and spectral details.]