1-[2-(4-ethynyl-2-fluoro-phenylamino)-3,4-difluoro-phenyl]-ethanone | 833451-92-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-(4-ethynyl-2-fluoro-phenylamino)-3,4-difluoro-phenyl]-ethanone
• 英文别名: Ethanone, 1-[2-[(4-ethynyl-2-fluorophenyl)amino]-3,4-difluorophenyl]-；1-[2-(4-ethynyl-2-fluoroanilino)-3,4-difluorophenyl]ethanone
• CAS: 833451-92-6
• 化学式: C₁₆H₁₀F₃NO
• 分子量: 289.257
• InChiKey: KCYHXYDHBMEWNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)phenyl)-ethanone 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以70%的产率得到1-[2-(4-ethynyl-2-fluoro-phenylamino)-3,4-difluoro-phenyl]-ethanone
  参考文献：
  名称：

  [EN] DIPHENYLAMINO KETONE DERIVATIVES AS MEK INHIBITORS
  [FR] DERIVES DE DIPHENYLAMINOCETONE UTILES COMME INHIBITEURS DE MEK

  摘要：

  本发明涉及二苯胺酮衍生物、药物组合物及其使用方法。

  公开号：

  WO2005007616A1

文献信息

• Diphenylamino ketone derivatives as MEK inhibitors
  申请人：Barrett Douglas Stephen

  公开号：US20050059710A1

  公开（公告）日：2005-03-17

  The present invention relates to diphenylamino ketone derivatives, pharmaceutical compositions and methods of use thereof.

  本发明涉及二苯胺酮衍生物、制药组合物及其使用方法。
• PROCESS FOR PRODUCING THERMOPLASTIC RESIN FILM
  申请人：Yupo Corporation

  公开号：EP1486529A1

  公开（公告）日：2004-12-15

  Disclosed is a method for producing a thermoplastic resin film, which comprises oxidizing the surface of a thermoplastic resin film (i) that contains an unsaturated carboxylic acid-modified polyolefin-based resin, then applying a surface modifier thereto, and stretching it. According to the method, thermoplastic resin films can be produced that have good adhesiveness between the film substrate and the coating layer thereof and have good printability and electrostatic resistance.

  本发明公开了一种生产热塑性树脂薄膜的方法，该方法包括氧化含有不饱和羧酸改性聚烯烃基树脂的热塑性树脂薄膜(i)的表面，然后在其上涂抹表面改性剂，并对其进行拉伸。根据该方法，可以生产出在薄膜基材和涂布层之间具有良好粘合性、良好印刷性和抗静电性的热塑性树脂薄膜。
• Method for producing thermoplastic resin film
  申请人：Iida Seiichiro

  公开号：US20050085579A1

  公开（公告）日：2005-04-21

  Disclosed is a method for producing a thermoplastic resin film, which comprises oxidizing the surface of a thermoplastic resin film (i) that contains an unsaturated carboxylic acid-modified polyolefin-based resin, then applying a surface modifier thereto, and stretching it. According to the method, thermoplastic resin films can be produced that have good adhesiveness between the film substrate and the coating layer thereof and have good printability and electrostatic resistance.
• [EN] DIPHENYLAMINO KETONE DERIVATIVES AS MEK INHIBITORS<br/>[FR] DERIVES DE DIPHENYLAMINOCETONE UTILES COMME INHIBITEURS DE MEK
  申请人：WARNER LAMBERT CO

  公开号：WO2005007616A1

  公开（公告）日：2005-01-27

  The present invention relates to diphenylamino ketone derivatives, pharmaceutical compositions and methods of use thereof.

  本发明涉及二苯胺酮衍生物、药物组合物及其使用方法。