5,8-Quinolinedione, 7-((2-(4-morpholinyl)ethyl)amino)- | 874351-38-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,8-Quinolinedione, 7-((2-(4-morpholinyl)ethyl)amino)-
• 英文别名: 7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione
• CAS: 874351-38-9
• 化学式: C₁₅H₁₇N₃O₃
• 分子量: 287.31
• InChiKey: QWIRJCMQNFHGJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20140135325A1

  公开（公告）日：2014-05-15

  The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.
• Novel Ezrin Inhibitors and Methods of Making and Using
  申请人：Georgetown University

  公开号：US20180148437A1

  公开（公告）日：2018-05-31

  The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growh of a cancer cell.
• US9522908B2
  申请人：——

  公开号：US9522908B2

  公开（公告）日：2016-12-20
• [EN] INHIBITORS OF CANCER STEM CELLS<br/>[FR] INHIBITEURS DE CELLULES SOUCHES CANCÉREUSES
  申请人：UNIV PITTSBURGH

  公开号：WO2011130677A1

  公开（公告）日：2011-10-20

  A method of treating cancer in a subject, comprising co-administering to the subject (a) a therapeutically effective amount of at least one compound that selectively targets cancer stem cells, wherein the compound is selected from an indenoisoquinoline compound, a naphthoquinone compound, a quinolinedione compound, bouvardin, A-77636, rottlerin, or CGP-74514A, or a pharmaceutically acceptable salt or ester thereof, and (b) a therapeutically effective amount of at least one anti-cancer agent.
• [EN] NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING<br/>[FR] NOUVEAUX INHIBITEURS D'EZRINE ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：UNIV GEORGETOWN

  公开号：WO2012064396A2

  公开（公告）日：2012-05-18

  The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.