3,9,15,21-Tetratert-butyl-26,26,28,28-tetra(propan-2-yl)-25,27,29-trioxa-6,12,18,31-tetrathia-26,28-disilahexacyclo[21.7.1.17,11.113,17.05,30.019,24]tritriaconta-1,3,5(30),7,9,11(33),13(32),14,16,19(24),20,22-dodecaene-32,33-diol | 430452-13-4

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 3,9,15,21-Tetratert-butyl-26,26,28,28-tetra(propan-2-yl)-25,27,29-trioxa-6,12,18,31-tetrathia-26,28-disilahexacyclo[21.7.1.17,11.113,17.05,30.019,24]tritriaconta-1,3,5(30),7,9,11(33),13(32),14,16,19(24),20,22-dodecaene-32,33-diol
• CAS: 430452-13-4；699001-14-4
• 化学式: C₅₂H₇₄O₅S₄Si₂
• 分子量: 963.592
• InChiKey: RGKLXGYJXDSSFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.52
• 重原子数：
  63
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  169
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  3,9,15,21-Tetratert-butyl-26,26,28,28-tetra(propan-2-yl)-25,27,29-trioxa-6,12,18,31-tetrathia-26,28-disilahexacyclo[21.7.1.17,11.113,17.05,30.019,24]tritriaconta-1,3,5(30),7,9,11(33),13(32),14,16,19(24),20,22-dodecaene-32,33-diol 在 四丁基氟化铵 、 caesium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 31.0h， 生成 5,11,17,23-tetra-tert-butyl-25,26-dihydroxy-27,28-(1,4,7,10-tetraoxadecane-1,10-diyl)thiacalix[4]arene
  参考文献：
  名称：

  First synthesis of 25,26-bridged thiacalix[4]crowns by the use of a 25,26-O-disiloxanediyl-capped p-tert-butylthiacalix[4]arene

  摘要：

  通过用以下物质处理容易获得的 25,26-O-四异丙基二硅氧烷二基封端的对叔丁基 thiacalix[4] 芳烃 (3)，首次简便地合成了 25,26-桥联 thiacalix[4] 冠 (2a-f)。双官能烷基化剂 (5a–f) 和随后的脱甲硅烷基化。

  DOI：

  10.1039/b206050g
• 作为产物：
  描述：

  4-叔丁基苯酚 在 咪唑 、 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 11.0h， 生成 3,9,15,21-Tetratert-butyl-26,26,28,28-tetra(propan-2-yl)-25,27,29-trioxa-6,12,18,31-tetrathia-26,28-disilahexacyclo[21.7.1.17,11.113,17.05,30.019,24]tritriaconta-1,3,5(30),7,9,11(33),13(32),14,16,19(24),20,22-dodecaene-32,33-diol
  参考文献：
  名称：

  一种用于检测Zn²⁺的荧光探针、制备方法及其应用

  摘要：

  本申请公开了一种荧光探针，其结构式如下： 制备时，在N

  公开号：

  CN116120359A

文献信息

• First synthesis of 25,26-bridged thiacalix[4]crowns by the use of a 25,26-O-disiloxanediyl-capped p-tert-butylthiacalix[4]arene
  作者：Fumitaka Narumi、Nobuji Matsumura、Naoya Morohashi、Hiroshi Kameyama、Sotaro Miyano

  DOI：10.1039/b206050g

  日期：2002.8.8

  The first and facile synthesis of 25,26-bridged thiacalix[4]crowns (2a–f) is disclosed by treatment of readily available 25,26-O-tetraisopropyldisiloxanediyl-capped p-tert-butylthiacalix[4]arene (3) with difunctional alkylating agents (5a–f) and subsequent desilylation.

  通过用以下物质处理容易获得的 25,26-O-四异丙基二硅氧烷二基封端的对叔丁基 thiacalix[4] 芳烃 (3)，首次简便地合成了 25,26-桥联 thiacalix[4] 冠 (2a-f)。双官能烷基化剂 (5a–f) 和随后的脱甲硅烷基化。
• Proximal O,O′-capped calix[4]arenes with a disiloxane bridge as highly efficient synthetic intermediates for 1,2-dialkylation at the lower rim
  作者：Fumitaka Narumi、Naoya Morohashi、Nobuji Matsumura、Nobuhiko Iki、Hiroshi Kameyama、Sotaro Miyano

  DOI：10.1016/s0040-4039(01)02202-x

  日期：2002.1

  Treatment of calix[4]arenes with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane using imidazole as a base yielded O,O′-bridged calixarenes in excellent yields, which were subsequently treated with an alkyl halide/base to give O″,O‴-dialkylated products in high yields. These were, in turn, amenable to fluoride-promoted quantitative desilylation, thus providing an efficient method for the net proximal

  杯的治疗[4]使用咪唑作为碱，得到1,3-二氯- 1,1,3,3-四异丙基芳烃Ö，ö '-bridged杯芳烃以优良产率，其随后用烷基卤处理/碱为了让Ø “ Ø '''二烷基化产品的高收益。这些反过来又适合氟化物促进的定量脱甲硅烷基化，因此为下边缘杯[4]芳烃的净近端二烷基化提供了一种有效的方法。
• Stereoselective dialkylation of the proximal hydroxy groups of calix- and thiacalix[4]arenes
  作者：Fumitaka Narumi、Tetsutaro Hattori、Naoya Morohashi、Nobuji Matsumura、Waka Yamabuki、Hiroshi Kameyama、Sotaro Miyano

  DOI：10.1039/b315867e

  日期：——

  Treatment of p-tert-butylcalix[4]arene (C1) and its sulfur-bridged analog T1 with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane in the presence of imidazole gives proximally O,O'-disiloxane-1,3-diyl-bridged calixarenes C2 and T2 in excellent yields, respectively. Subsequent base-catalyzed etherification of the remaining hydroxy groups with alkyl halides gives syn- and anti-O'',O'''-dialkylated products

  在咪唑存在下，用1,3-二氯-1,1,3,3-四异丙基二硅氧烷处理对叔丁基杯[4]芳烃（C1）及其硫桥键类似物T1，得到近端的O，O'-二硅氧烷-1,3-二基桥接杯芳烃C2和T2分别具有出色的收率。随后，其余的羟基与烷基卤进行碱催化的醚化反应，生成顺-和反-O''，O'''-二烷基化产物，其立体选择性取决于大环化合物以及金属阳离子的性质所使用的基础。因此，传统的杯芳烃C2借助叔丁醇钾和K（2）CO（3）优先提供1,2-交替构象（C3）的合成化合物，以及具有Cs（2）的部分圆锥构象（C4）的反对应物）CO（3）。另一方面，硫杂杯芳烃T2可提供1的合成化合物 具有任何碱基的2-交替构象（T3）。通过用四丁基氟化铵处理，可以容易地除去所得产物的二硅氧烷二基桥。因此，净工艺为近端二烷基化杯[4]芳烃的区域和立体选择性合成提供了一种有效的方法。
• Stereoselective synthesis of all stereoisomers of vicinal and distal bis(O-2-aminoethyl)-p-tert-butylthiacalix[4]arene
  作者：Vandana Bhalla、Manoj Kumar、Tetsutaro Hattori、Sotaro Miyano

  DOI：10.1016/j.tet.2004.05.035

  日期：2004.7

  O,O"- and O,O'-bis(2-aminoethyl)-p-tert-butylthiacalix[4]arenes of anti conformation have been prepared by the reduction of the corresponding O,O"- and O,O'-bis(cyanomethyl) ethers. Their syn-O,O"- and O,O'-counterparts have been prepared by alternative routes via the Mitsunobu reaction of thiacalix[4]arene with N-(2-hydroxyethyl)phthalimide and the reduction of a O,O'-disiloxanediyl-bridged O",O"'-bis(cyanomethyl) ether of 1,2-alternate conformation, respectively. These products are expected to serve as useful precursors of highly elaborated synthetic receptors, including biscalixarenes. (C) 2004 Elsevier Ltd. All rights reserved.
• Synthesis of an inherently chiral O,O′-bridged thiacalix[4]crowncarboxylic acid and its application to a chiral solvating agent
  作者：Fumitaka Narumi、Tetsutaro Hattori、Nobuji Matsumura、Toru Onodera、Hiroshi Katagiri、Chizuko Kabuto、Hiroshi Kameyama、Sotaro Miyano

  DOI：10.1016/j.tet.2004.06.074

  日期：2004.8

  Treatment of readily available O,O'-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl-bridged p-tert-butylthiacalix[4]arene (1) with tri(ethylene glycol) di-p-tosylate and subsequent desilylation gave O,O'-bridged thiacalix [4] crown 3 in an excellent yield. Mono-O-alkylation of 3 with ethyl bromoacetate, followed by optical resolution by chiral HPLC, and subsequent hydrolysis of the ester moiety gave inherently chiral O,O'-bridged thiacalix[4]crowncarboxylic acid (+)-6, which clearly discriminated enantiomeric primary amines, as well as amino esters, by H-1 NMR spectroscopy. (C) 2004 Elsevier Ltd. All rights reserved.