2-methylquinoline-8-thiol | 10222-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-methylquinoline-8-thiol
• 英文别名: 8-SH-2-Me-quinoline；8-Quinolinethiol, 2-methyl-
• CAS: 10222-10-3
• 化学式: C₁₀H₉NS
• 分子量: 175.254
• InChiKey: DUIAZPVQMPQZSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  13.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methylquinoline-8-thiol 、 cobalt ferrocyanide 在 氧气 作用下， 以 水 为溶剂， 生成 bis(2-methyl-8-quinolinethiolato)cobalt(II)
  参考文献：
  名称：

  Mikhailov, Russian Journal of General Chemistry, 1998, vol. 68, # 10, p. 1650 - 1655

  摘要：

  DOI：
• 作为产物：
  描述：

  8-(tert-butylthio)-2-methylquinoline 在 盐酸 作用下， 反应 12.0h， 以88%的产率得到2-methylquinoline-8-thiol
  参考文献：
  名称：

  Preparation and evaluation of sulfur-containing metal chelators

  摘要：

  为探究G蛋白偶联受体的结构和功能，成功合成了功能化的8-巯基喹啉衍生物和2-(2-吡啶基)苯并噻吩。开发了一种基于荧光的方法来测定这些金属螯合剂对锌离子的亲和力。

  DOI：

  10.1039/b307399h

文献信息

• [EN] INHIBITORS OF RPN11<br/>[FR] INHIBITEURS DE RPN11
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2017031255A1

  公开（公告）日：2017-02-23

  Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.

  候选用于特定抑制Rpn11的化合物由Formula 1a代表，其中R2、R3、R4、R5、R6和R7中的每一个独立选择自氢（H）、取代和未取代的烷基基团、羧基团或取代和未取代的羧酰胺。
• Preparation and evaluation of sulfur-containing metal chelators
  作者：Sylvain Clavier、Øystein Rist、Stina Hansen、Lars-Ole Gerlach、Thomas Högberg、Jan Bergman

  DOI：10.1039/b307399h

  日期：——

  With a view to probe the structure and function of G-protein coupled receptors the synthesis of functionalized 8-mercaptoquinoline derivatives and 2-(2-pyridyl)thiophenol was achieved. A fluorescence-based method for determining the affinity of these metal chelators toward zinc ions was developed.

  为探究G蛋白偶联受体的结构和功能，成功合成了功能化的8-巯基喹啉衍生物和2-(2-吡啶基)苯并噻吩。开发了一种基于荧光的方法来测定这些金属螯合剂对锌离子的亲和力。
• Process For The Preparation Of A Metal-Organic Compound Comprising At Least One Imine Ligand
  申请人：Ijpeij Edwin

  公开号：US20070219376A1

  公开（公告）日：2007-09-20

  The invention relates to a process for the preparation of a metal-organic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula I or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula 2 In the presence of at least 1, respectively at least 2 equivalents of a base, with Y═N—R   as formula 1, wherein Y is selected from a substituted carbon, nitrogen, or phosphorous atom and R represents a substituent, and with M V (L 1 ) k (L 2 ) l (L 3 ) m (L 4 ) n X   as formula 2, wherein: M represents a group 4 or group 5 metal ion V represents the valency of the metal ion, being 3, 4 or 5 L 1 , L 2 , L 3 , and L 4 represent a ligand or a group 17 halogen atom on M and may be equal or different X represents a group 17 halogen atom, k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+1=V. The invention further relates to a process for the preparation of a polyolefin in the presence of the compound prepared according to the process of the invention.

  本发明涉及一种制备至少含有一种亚胺配体的金属有机化合物的方法，其特征在于将式I或其HA加合物中的亚胺配体与式2的金属有机试剂接触，在至少1个或2个当量的碱存在下进行，其中HA代表酸，其中H代表其质子，A代表其共轭碱基，式1中，Y═N—R，其中Y选自取代的碳、氮或磷原子，R代表取代基，式2中，MV（L1）k（L2）l（L3）m（L4）nX，其中：M代表4族或5族金属离子，V代表金属离子的价态为3、4或5，L1、L2、L3和L4代表M上的配体或17族卤素原子，可以相同也可以不同，X代表17族卤素原子，k、l、m、n=0、1、2、3、4，其中k+l+m+n+1=V。本发明还涉及一种在本发明方法制备的化合物存在下制备聚烯烃的方法。
• Process for the Preparation of a Metal-Organic Compound Comprising at Least One Imine Ligand
  申请人：Ijpeij Edwin

  公开号：US20080045719A1

  公开（公告）日：2008-02-21

  The invention relates to a process for the preparation of a metal-organic compound, comprising at least one phosphinimine ligand, characterized in that the HA adduct of a phosphinimine ligand according to formula (1) is contacted with a metal-organic reagent of formula (2) in the presence of at least 2 equivalents of a base, wherein HA represents an acid, of which H represents its proton and A its conjugate base, with Y═N—H as formula (1), and M v (L 1 ) k (L 2 ) 1 (L 3 ) m (L 4 ) n X as formula (2), and wherein Y is a substituted phosphorous atom, and M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5 L 1 , L 2 , L 3 , and L 4 represent a ligand or a group 17 halogen atom on M and may be equal or different, k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+l=V, and X represents a group 17 halogen atom. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal-organic compound is activated anywhere in, or before a polymerisation reactor.

  本发明涉及一种制备至少含有一个膦亚胺配体的金属有机化合物的方法，其特征在于将公式（1）的膦亚胺配体的HA加合物与公式（2）的金属有机试剂在至少2当量的碱存在下接触，其中HA代表一种酸，H代表其质子，A代表其共轭碱基，Y═N—H为公式（1），Mv(L1)k(L2)1(L3)m(L4)nX为公式（2)，其中Y为取代的磷原子，M代表4族或5族金属离子，V代表金属离子的价，为3、4或5，L1、L2、L3和L4代表M上的配体或17族卤素原子，可以相同或不同，k、l、m、n=0、1、2、3、4，其中k+l+m+n+l=V，X代表17族卤素原子。本发明还涉及一种通过制备本发明方法的金属有机化合物来制备聚烯烃的方法，其中碱是与烯烃聚合兼容的碱，所述金属有机化合物在聚合反应器内或之前的任何地方被活化。
• Polymerization Catalyst Comprising Amidine Ligand
  申请人：Ijpeij Edwin

  公开号：US20090012246A1

  公开（公告）日：2009-01-08

  The invention relates to a process for the preparation of a polymer comprising at least one aliphatic or aromatic hydrocarbyl C 2-20 olefin in the presence of an ionic catalyst comprising an organometallic compound and an activator, and optionally a scavenger, characterized in that the organometallic compound is a compound according to formula (1): where: M is a metal of group 3, 4, 5, 6 or 7, or the lanthanide series, and p is the valency of the metal M, A represents a neutral or anionic spectator ligand whose valency v is 0, 1 or 2, and q is an integer denoting the number of spectator ligands A, Z is an optional bridging moiety, n is the integer number of parallel bridging moieties Z, Y is an amidine-containing spectator ligand represented by formula (2): wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, Sub 1 is a substituent, which comprises a group 14 atom through which Sub 1 is bonded to the imine carbon atom. Sub 2 is a substituent, which comprises a heteroatom of group 15-16, through which Sub 2 is bonded to the imine carbon atom, r is an integer >0, L is an optional neutral Lewis basic ligand, j is an integer denoting the number of neutral ligands L, and X is an anionic ligand. The invention further relates to a organometallic compound according to formula (1) and a process for the preparation of this compound as well as to a UHMWPE having a weight average molecular weight of at least 4.000 kg/mol and a molecular weight distribution M w /M n of less than 2.6.

  本发明涉及一种制备聚合物的方法，该聚合物包含至少一种脂肪族或芳香族C2-20烯烃，在离子催化剂的存在下进行。该离子催化剂包括一个有机金属化合物和一个活化剂，以及可选的清除剂。其中，所述有机金属化合物是符合以下公式（1）的化合物： 其中：M是3、4、5、6或7族金属或稀土系列金属，p是金属M的价，A代表中性或负离子观察配体，其价为0、1或2，q是表示观察配体A的数量的整数，Z是可选的桥接基团，n是平行桥接基团Z的整数，Y是含有酰胺基的观察配体，其由以下公式（2）表示： 其中，含有酰胺基的配体通过亚胺氮原子与金属M共价键合，Sub1是一个取代基，其中包括一个14族元素基团，通过Sub1与亚胺碳原子键合。Sub2是一个取代基，其中包括一个15-16族杂原子，通过Sub2与亚胺碳原子键合。r是大于0的整数，L是可选的中性路易斯碱配体，j是表示中性配体L的数量的整数，X是一个负离子配体。本发明还涉及符合公式（1）的有机金属化合物的制备方法，以及具有重量平均分子量至少为4.000 kg/mol，分子量分布Mw/Mn小于2.6的超高分子量聚乙烯的制备方法。