3-(己氧基)丙胺 | 16728-61-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-(己氧基)丙胺
• 中文别名: 己基胺丙基醚；3-己氧基丙胺
• 英文名称: 3-Aminopropyl-hexylether
• 英文别名: γ-n-Hexoxypropylamin；γ-n-Hexyloxy-propylamin；3-hexyloxypropylamine；3-hexoxypropylamine；3-(Hexyloxy)propylamine；3-hexoxypropan-1-amine
• CAS: 16728-61-3
• 化学式: C₉H₂₁NO
• 分子量: 159.272
• InChiKey: NWGJTXNNXLHFSE-UHFFFAOYSA-N

物化性质

• 沸点：
  229.7±13.0 °C(Predicted)
• 密度：
  0.851±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  3-(己氧基)丙胺 、 2-(4-氯苯基)苯胺 在 乙醇 作用下， 生成 1-(3-hexyloxy-propyl)-4-(2-methoxy-phenyl)-piperazine
  参考文献：
  名称：

  US2891063

  摘要：

  公开号：
• 作为产物：
  描述：

  3-(己氧基)丙腈 在 Rh catalyst 氨 、 氢气 作用下， 以 乙醇 为溶剂， 生成 3-(己氧基)丙胺
  参考文献：
  名称：

  A Low Pressure Process for the Reduction of Nitriles. Use of Rhodium Catalyst¹

  摘要：

  DOI：

  10.1021/ja01494a067

文献信息

• Substituted dialkanolamines, sulfur analogs and condensed 1,4-oxazine
  申请人：A. H. Robins Company, Incorporated

  公开号：US04803200A1

  公开（公告）日：1989-02-07

  Substituted dialkanolamines, oxazine and sulfur analogs thereof, useful in treating shipping fever syndrome in mammals are disclosed having the formula: ##STR1## wherein: Ar is ##STR2## Z is oxygen or sulfur; R is selected from hydrogen, loweralkyl or ##STR3## R.sup.1 R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are selected from hydrogen or loweralkyl; and ##STR4## when taken together may form a lowercycloalkyl ring or R.sup.5 with --ZR.sup.2 when taken together may form a 5-membered saturated oxygen or sulfur containing heterocyclic ring; X is selected from hydrogen, halo, loweralkoxy, loweralkyl, trifluoromethyl or dimethylamino and when X is more than 1, it may be the same radical or different; y is 0, 1 or 2; n is one, or zero and when n is 1, the stereoisomers thereof and when n is zero the dotted line becomes an oxygen-carbon bond forming an oxazine ring and the pharmaceutically acceptable acid addition salts thereof.

  揭示了在治疗哺乳动物的运输热症候群中有用的取代二烷醇胺、噁唑和其硫代物，其化学式为：##STR1##其中：Ar为##STR2##Z为氧或硫；R从氢、低烷基或##STR3##中选择；R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、R.sup.6和R.sup.7中选择自氢或低烷基；和##STR4##当一起取时，可能形成低环烷基环，或者R.sup.5与--ZR.sup.2一起取时，可能形成含氧或硫的5-成员饱和杂环环；X从氢、卤素、低烷氧基、低烷基、三氟甲基或二甲氨基中选择，当X大于1时，可能是相同的基团或不同的基团；y为0、1或2；n为1或零，当n为1时，其立体异构体，当n为零时，虚线变成氧-碳键形成噁唑环及其药用盐。
• Derivatives of 2-amino-1-phenylethanol having antiulcer activity
  申请人：A. H. Robins Company, Incorporated

  公开号：US05171753A1

  公开（公告）日：1992-12-15

  Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted phenyl and C is a linking group or terminal group. The compounds of this invention can inhibit ulceration in in-vivo studies in rats.

  2-氨基-1-苯基乙醇的衍生物通过取代胺和苯偶姻、芪氧化物或苯乙烯氧化物制备，得到如下通式的化合物：##STR1## 其中R为H或(未)取代的苯基，C为连接基团或端基团。本发明的这些化合物能够在体内研究中抑制大鼠的溃疡形成。
• N,N'-dialkyl derivatives of polyhydroxyalkyl alkylenediamines
  申请人：Ford Edward Michael

  公开号：US20060013780A1

  公开（公告）日：2006-01-19

  Surfactant compositions containing compounds according to structure (I), and methods of making them, are disclosed. The compounds provide reduced dynamic and equilibrium surface tension, good solubility, moderate foaming, and good cleaning performance. The methods for making them involve reaction of N-(polyhydroxyalkyl)-alkylamines with dinitriles, dialdehydes, or acetals or hemiacetals of dialdehydes in the presence of hydrogen and a transition metal catalyst. In structure (I), x is an integer from about 1 to 12, R 1 and R 2 are independently C3-C30 linear alkyl, cyclic alkyl, branched alkyl, alkenyl, aryl, alkylaryl, alkoxyalkyl, and dialkylaminoalkyl; and R 3 and R 4 are independently hydrogen or a pyranosyl group such as α-D-glucopyranosyl, β-D-glucopyranosyl, or β-D-galactopyranosyl.

  含有结构（I）中化合物的表面活性剂组合物以及制备它们的方法已被披露。这些化合物提供了降低的动态和平衡表面张力、良好的溶解性、适度的起泡性能和良好的清洁性能。制备它们的方法涉及N-(多羟基烷基)-烷基胺与二腈、二醛或二醛的缩醛或半缩醛在氢气和过渡金属催化剂存在下的反应。在结构（I）中，x是约1到12之间的整数，R1和R2独立地为C3-C30线性烷基、环烷基、支链烷基、烯烃、芳基、烷基芳基、烷氧基烷基和二烷基氨基烷基；R3和R4独立地为氢或吡喃基团，如α-D-葡萄糖吡喃基、β-D-葡萄糖吡喃基或β-D-半乳糖吡喃基。
• Amphoteric surfactants based upon epoxy succinic acid
  申请人：Applied Carbo Chemicals INC

  公开号：US06346648B1

  公开（公告）日：2002-02-12

  The present invention deals with novel compounds their applications and a process their preparation. The compounds are novel amphoteric surfactants that contain a hydroxyl group and two carboxylic groups per hydroxyl group. The compounds have a unique structure, having multiple carboxyl groups on each amino group. The utility for these novel polymers is as softening, anti-tangle, and conditioning agents for use in personal care, textile and related applications.

  本发明涉及新化合物及其应用和制备过程。这些化合物是新型两性表面活性剂，每个羟基中含有一个羟基和两个羧基。这些化合物具有独特的结构，在每个氨基上具有多个羧基。这些新型聚合物的用途是作为个人护理、纺织和相关应用中的柔软、防缠结和调理剂。
• Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors
  申请人：——

  公开号：US20030134849A1

  公开（公告）日：2003-07-17

  A compound of formula (I) in which R 1 is halo, lower alkoxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterecyclic group or optionally substituted lower alkynyl, R 2 is amidated carboxy, R 3 is hydrogen or acyl, Ar is aryl or heterocyclic group, X is thia, sulfinyl or sulfonyl, Y and Z are each lower alkylene, m and n are each an integer of 0 to 2, and a salt thereof, useful as inhibitors of matrix metalloproteinases (MMP) or the production of tumor necrosis factor &agr; (TNF &agr;).

  式(I)的化合物，其中R1是卤素、低碳氧基、可选取代芳基、可选取代芳氧基、可选取代杂环基或可选取代低炔基，R2是酰胺化羧基，R3是氢或酰基，Ar是芳基或杂环基，X是硫代、亚砜基或磺酰基，Y和Z是各自的低碳链基，m和n分别是0到2的整数，以及其盐，用作基质金属蛋白酶（MMP）抑制剂或肿瘤坏死因子α（TNFα）的产生。