2-[6-(6,6-Dimethyl-4,8-dioxaspiro[2.5]oct-1-en-2-yl)hexyl]-6,6-dimethyl-4,8-dioxaspiro[2.5]oct-1-ene | 181883-64-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[6-(6,6-Dimethyl-4,8-dioxaspiro[2.5]oct-1-en-2-yl)hexyl]-6,6-dimethyl-4,8-dioxaspiro[2.5]oct-1-ene
• CAS: 181883-64-7
• 化学式: C₂₂H₃₄O₄
• 分子量: 362.51
• InChiKey: YCBCCVYDAPKIFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[6-(6,6-Dimethyl-4,8-dioxaspiro[2.5]oct-1-en-2-yl)hexyl]-6,6-dimethyl-4,8-dioxaspiro[2.5]oct-1-ene 在 silver trifluoromethanesulfonate 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以6%的产率得到1,4-bis(2,2-dimethyl-3-hydroxypropoxycarbonyl)-(E)-1,(E)-3-cyclodecadiene
  参考文献：
  名称：

  Macrocarbocycle Synthesis by Copper- and Silver-Mediated Cyclization of Tethered Cyclopropenone Acetals. Electronic Tuning of Metal Vinylcarbene Complex into Vinylmetallic Species

  摘要：

  [GRAPHICS]Synthesis of n-membered medium and macrocarbocycles through intramolecular sp(2)-sp(2) C-C bond formation was achieved with the aid of CuOTf or AgOTf by intramolecular coupling reaction of cyclopropenone acetals tethered by a methylene chain of (n - 4) carbon atoms, The reaction has proved to be useful for the synthesis of large carbocycles (n > 13) in yields as high as 78%, and most notably also for an eight-membered carbocycle in 88% yield.

  DOI：

  10.1021/ol990053p
• 作为产物：
  描述：

  1,6-二碘己烷 、 6,6-二甲基-4,8-二氧杂螺[2.5]辛-1-烯 在 正丁基锂 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 为溶剂， 生成 2-[6-(6,6-Dimethyl-4,8-dioxaspiro[2.5]oct-1-en-2-yl)hexyl]-6,6-dimethyl-4,8-dioxaspiro[2.5]oct-1-ene
  参考文献：
  名称：

  Regio- and diastereo-controlled double cycloaddition to [60] fullerene: one-step synthesis of Cs and C2 chiral organofullerenes with new tris-annulating reagents

  摘要：

  新型三重环加成试剂对 [60]富勒烯进行双环加成，形成了构建在 [60]富勒烯球体上的三环系统，提供了Cs对称和C2手性的非消旋有机富勒烯。

  DOI：

  10.1039/cc9960001747

文献信息

• Regio- and diastereo-controlled double cycloaddition to [60] fullerene: one-step synthesis of Cs and C2 chiral organofullerenes with new tris-annulating reagents
  作者：Eiichi Nakamura、Hiroyuki Isobe、Hidetoshi Tokuyama、Masaya Sawamura

  DOI：10.1039/cc9960001747

  日期：——

  Double cycloaddition of new tris-annulation reagents to [60]fullerene creates a tricyclic system constructed on the [60]fullerene sphere, providing Cs symmetric and C2 chiral non-racemic organofullerenes.

  新型三重环加成试剂对 [60]富勒烯进行双环加成，形成了构建在 [60]富勒烯球体上的三环系统，提供了Cs对称和C2手性的非消旋有机富勒烯。
• Synthetic and Computational Studies on Symmetry-Defined Double Cycloaddition of a New Tris-Annulating Reagent to C₆₀
  作者：Hiroyuki Isobe、Hidetoshi Tokuyama、Masaya Sawamura、Eiichi Nakamura

  DOI：10.1021/jo970685u

  日期：1997.7.1

  For the purpose of doubly functionalizing fullerenes, new tris-annulating reagents 2(n) have been developed. The reagents carry, in one molecule, two cyclopropenone acetals which are connected with an n-carbon methylene tether. Upon thermolysis of 2(n) in the presence of C-60, the reagent undergoes [3 + 2] cycloaddition reaction twice in a regio- and stereoselective manner to give C-s and C-2 organofullerenes bearing two cyclopentenone acetals. The selectivity varies as the function of the tether structure. The experiments have shown that, in each series of different tether lengths, one can obtain one or two diastereomeric double adducts out of several structural possibilities. The selectivity of the reaction did not conform to the prediction made on the basis of previous knowledge on intermolecular double additions but was found to be correlated to the conformational strain of the tether moiety, which can be estimated by a newly developed ''double differential protocol''. Systematic studies on the reliability of various computational methods for organofullerenes indicated that certain molecular orbital and molecular mechanics calculations give very reliable structural data while certain others do not.
• Macrocarbocycle Synthesis by Copper- and Silver-Mediated Cyclization of Tethered Cyclopropenone Acetals. Electronic Tuning of Metal Vinylcarbene Complex into Vinylmetallic Species
  作者：Yong Yu、Masahiro Yamanaka、Eiichi Nakamura

  DOI：10.1021/ol990053p

  日期：1999.8.1

  [GRAPHICS]Synthesis of n-membered medium and macrocarbocycles through intramolecular sp(2)-sp(2) C-C bond formation was achieved with the aid of CuOTf or AgOTf by intramolecular coupling reaction of cyclopropenone acetals tethered by a methylene chain of (n - 4) carbon atoms, The reaction has proved to be useful for the synthesis of large carbocycles (n > 13) in yields as high as 78%, and most notably also for an eight-membered carbocycle in 88% yield.