(2R,3R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-2-<(4S)-2,2-dimethyl-1,3-dioxolan-4-yl>-2,3-dihydro-3,4,5-trimethyl-6H-pyran | 150254-43-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-2-<(4S)-2,2-dimethyl-1,3-dioxolan-4-yl>-2,3-dihydro-3,4,5-trimethyl-6H-pyran
• 英文别名: tert-butyl-[[(2R,3R,6S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3,4,5-trimethyl-3,6-dihydro-2H-pyran-6-yl]oxy]-dimethylsilane
• CAS: 150254-43-6
• 化学式: C₁₉H₃₆O₄Si
• 分子量: 356.578
• InChiKey: ZMFRFTJTYHREJO-XBVQOTNRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.86
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2R,3R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-2-<(4S)-2,2-dimethyl-1,3-dioxolan-4-yl>-2,3-dihydro-3,4,5-trimethyl-6H-pyran 在 吡啶 、 四氧化锇 、 sodium hydrogensulfite 作用下， 生成 (2R,3S,4R,5R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-2-<(4S)-2,2-dimethyl-1,3-dioxolan-4-yl>-3,4,5,6-tetrahydro-3,4,5-trimethyl-2H-pyran-4,5-diol
  参考文献：
  名称：

  Synthetic studies on macropyrrolizidine alkaloid, monocrotaline: enantioselective synthesis of a necic acid moiety, monocrotalic acid methylene acetal

  摘要：

  A methylene acetal derivative 4 of the necic acid, monocrotalic acid, part of the macropyrrolizidine alkaloid, monocrotaline, was enantioselectively synthesized from 2-furylmethanol derivative 6. Oxidation of 6, followed by silylation of the resulting lactol 9, gave silyl ether 19 as a major product. Introduction of the di-tert-hydroxy groups to 22 was achieved by stereoselective dihydroxylation with osmium tetroxide. After protection of the vicinal diol as a methylenedioxy derivative, acetal 26 was successfully converted into the desired product 4.

  DOI：

  10.1021/jo00068a022
• 作为产物：
  描述：

  (2S,6S)-6-<(tert-Butyldimethylsilyl)oxy>-2-<(4S)-2,2-dimethyl-1,3-dioxolan-4-yl>-4,5-dimethyl-6H-pyran-3(2H)-one 在 rhodium on alumina potassium tert-butylate 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 25.0~70.0 ℃ 、101.33 kPa 条件下， 反应 2.5h， 生成 (2R,3R,6S)-6-<(tert-Butyldimethylsilyl)oxy>-2-<(4S)-2,2-dimethyl-1,3-dioxolan-4-yl>-2,3-dihydro-3,4,5-trimethyl-6H-pyran
  参考文献：
  名称：

  Synthetic studies on macropyrrolizidine alkaloid, monocrotaline: enantioselective synthesis of a necic acid moiety, monocrotalic acid methylene acetal

  摘要：

  A methylene acetal derivative 4 of the necic acid, monocrotalic acid, part of the macropyrrolizidine alkaloid, monocrotaline, was enantioselectively synthesized from 2-furylmethanol derivative 6. Oxidation of 6, followed by silylation of the resulting lactol 9, gave silyl ether 19 as a major product. Introduction of the di-tert-hydroxy groups to 22 was achieved by stereoselective dihydroxylation with osmium tetroxide. After protection of the vicinal diol as a methylenedioxy derivative, acetal 26 was successfully converted into the desired product 4.

  DOI：

  10.1021/jo00068a022

文献信息

• Synthetic studies on macropyrrolizidine alkaloid, monocrotaline: enantioselective synthesis of a necic acid moiety, monocrotalic acid methylene acetal
  作者：Toshio Honda、Kunio Tomitsuka、Masayoshi Tsubuki

  DOI：10.1021/jo00068a022

  日期：1993.7

  A methylene acetal derivative 4 of the necic acid, monocrotalic acid, part of the macropyrrolizidine alkaloid, monocrotaline, was enantioselectively synthesized from 2-furylmethanol derivative 6. Oxidation of 6, followed by silylation of the resulting lactol 9, gave silyl ether 19 as a major product. Introduction of the di-tert-hydroxy groups to 22 was achieved by stereoselective dihydroxylation with osmium tetroxide. After protection of the vicinal diol as a methylenedioxy derivative, acetal 26 was successfully converted into the desired product 4.