(S)-2-But-3-enyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propionaldehyde | 237736-77-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-2-But-3-enyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propionaldehyde
• 英文别名: (2S)-2-but-3-enoxy-3-[tert-butyl(dimethyl)silyl]oxypropanal
• CAS: 237736-77-5
• 化学式: C₁₃H₂₆O₃Si
• 分子量: 258.433
• InChiKey: MZKCRSWANBVLTJ-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.17
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  叔丁基二甲硅基三氟甲磺酸酯 、 烯丙基三丁基锡 、 (S)-2-But-3-enyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propionaldehyde 在 magnesium bromide 作用下， 生成 (4S,5S)-5-But-3-enyloxy-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-hex-1-ene
  参考文献：
  名称：

  Eight membered ethers via diene metathesis: Synthetic approach to laureatin natural products

  摘要：

  Ruthenium-mediated diene metathesis is applied to the synthesis of a range of oxocenes. The methodology is then utilised for the preparation of prelaureatin analogues. A successful synthesis of the 8-desalkyl analogue of prelaureatin in enantiomerically enriched form is described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00703-0
• 作为产物：
  描述：

  2-But-3-enyloxy-propane-1,3-diol 在 4-二甲氨基吡啶 、 porcine pancreatic lipase 、 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 (S)-2-But-3-enyloxy-3-(tert-butyl-dimethyl-silanyloxy)-propionaldehyde
  参考文献：
  名称：

  Eight membered ethers via diene metathesis: Synthetic approach to laureatin natural products

  摘要：

  Ruthenium-mediated diene metathesis is applied to the synthesis of a range of oxocenes. The methodology is then utilised for the preparation of prelaureatin analogues. A successful synthesis of the 8-desalkyl analogue of prelaureatin in enantiomerically enriched form is described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00703-0

文献信息

• Eight membered ethers via diene metathesis: Synthetic approach to laureatin natural products
  作者：Simon D. Edwards、Terence Lewis、Richard J.K. Taylor

  DOI：10.1016/s0040-4039(99)00703-0

  日期：1999.5

  Ruthenium-mediated diene metathesis is applied to the synthesis of a range of oxocenes. The methodology is then utilised for the preparation of prelaureatin analogues. A successful synthesis of the 8-desalkyl analogue of prelaureatin in enantiomerically enriched form is described. (C) 1999 Elsevier Science Ltd. All rights reserved.