3-(羟基甲基)-1H-吡唑-5-羧酸 | 949034-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 3-(羟基甲基)-1H-吡唑-5-羧酸
• 英文名称: 5-(hydroxymethyl)-1H-pyrazole-3-carboxylic acid
• 英文别名: 3-(hydroxymethyl)-1H-pyrazole-5-carboxylic acid
• CAS: 949034-44-0；1401555-38-1
• 化学式: C₅H₆N₂O₃
• mdl: MFCD16619746
• 分子量: 142.114
• InChiKey: OKEYZZIQFMYAIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.2
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2933199090

反应信息

• 作为反应物：
  描述：

  3-(羟基甲基)-1H-吡唑-5-羧酸 在 potassium permanganate 作用下， 生成 3,5-吡唑二甲酸
  参考文献：
  名称：

  Music Therapy with Alzheimer's Patients and Their Family Caregivers: A Pilot Project

  摘要：

  本文旨在介绍西班牙一家私人基金会（“Fundació la Caixa”）赞助的试点项目的结果，以展示音乐疗法的一些应用，并更系统地评估其对早期至中期阿尔茨海默氏病及相关疾病（ADRD）患者及其家庭护理人员的影响。该项目的对象是来自巴塞罗那郊区农村地区的14名阿尔茨海默氏病疑似患者（5名女性和9名男性）和14名家庭护理人员（9名女性和5名男性）。他们的年龄在70至80岁之间。在项目开始前，一位专门研究老年病的神经心理学家对参与者进行了一系列标准化测试。在项目结束前两天和两个月后，为了进行后续跟踪，再次进行了相同的测试。满意度问卷的结果表明，护理人员认为患者的社交和情感方面有所改善，统计测试表明以下测试的测试前后的得分存在显著差异：（a）痴呆量表（X2 = 12.29，p = .002），（b）NPI（X2 = 17.72，p = .001），（c）科恩-曼斯菲尔德躁动量表（X2 = 11.45，p = .003），（d）负担访谈（X2 = 9.19，p = .01），（e）记忆和行为问题清单（频率分量表）（X2 = 11.09，p

  DOI：

  10.1093/jmt/40.2.138
• 作为产物：
  描述：

  5-(羟甲基)吡唑-3-甲酸乙酯 生成 3-(羟基甲基)-1H-吡唑-5-羧酸
  参考文献：
  名称：

  Agonist lead identification for the high affinity niacin receptor GPR109a

  摘要：

  A strategy for lead identification of new agonists of GPR109a, starting from known compounds shown to activate the receptor, is described. Early compound triage led to the formulation of a binding hypothesis and eventually to our focus on a series of pyrazole acid derivatives. Further elaboration of these compounds provided a series of 5,5-fused pyrazoles to be used as lead compounds for further optimization. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.028

文献信息

• Mugnaini; Gruenanger, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, <hi>1953</hi>, vol. <8>14, p. 95,97,275,277
  作者：Mugnaini、Gruenanger

  DOI：——

  日期：——
• WO2024098066A1
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF<br/>[FR] DÉRIVÉS D'EXATECAN ET CONJUGUÉS ANTICORPS-MÉDICAMENT DE CEUX-CI
  申请人：[en]ALX ONCOLOGY INC.

  公开号：WO2022236136A1

  公开（公告）日：2022-11-10

  Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies.
• Agonist lead identification for the high affinity niacin receptor GPR109a
  作者：Tawfik Gharbaoui、Philip J. Skinner、Young-Jun Shin、Claudia Averbuj、Jae-Kyu Jung、Benjamin R. Johnson、Tracy Duong、Marc Decaire、Jane Uy、Martin C. Cherrier、Peter J. Webb、Susan Y. Tamura、Ning Zou、Nathalie Rodriguez、P. Douglas Boatman、Carleton R. Sage、Andrew Lindstrom、Jerry Xu、Thomas O. Schrader、Brian M. Smith、Ruoping Chen、Jeremy G. Richman、Daniel T. Connolly、Steven L. Colletti、James R. Tata、Graeme Semple

  DOI：10.1016/j.bmcl.2007.06.028

  日期：2007.9

  A strategy for lead identification of new agonists of GPR109a, starting from known compounds shown to activate the receptor, is described. Early compound triage led to the formulation of a binding hypothesis and eventually to our focus on a series of pyrazole acid derivatives. Further elaboration of these compounds provided a series of 5,5-fused pyrazoles to be used as lead compounds for further optimization. (C) 2007 Elsevier Ltd. All rights reserved.
• Music Therapy with Alzheimer's Patients and Their Family Caregivers: A Pilot Project
  作者：M. Brotons、P. Marti

  DOI：10.1093/jmt/40.2.138

  日期：2003.6.1

  The purpose of this paper is to present the results of a pilot project sponsored by a private foundation in Spain (“Fundació la Caixa”), in order to demonstrate some of the applications of music therapy, and to measure more systematically some of its effects on people with a probable diagnosis of Alzheimer's Disease and Related Disorders (ADRD) in early-moderate stages of the disease, and their family caregivers. Subjects for this project were 14 patients (5 women and 9 men) with a probable diagnosis of Alzheimer's disease, and 14 family caregivers (9 women and 5 men) from a rural area outside of Barcelona. Their age range was 70 to 80 years. Prior to the beginning of the project, a neuropsychologist specialized in gerontology administered a series of standardized tests to the participants. These same tests were administered again 2 days before the end of the project and 2 months later for follow-up purposes. The results of the satisfaction questionnaire showed that the caregivers perceived an improvement in the social and emotional areas of their patients, and statistical tests showed significant differences between pre and posttest scores in the following tests: (a) Dementia Scale (X2 = 12.29, p = .002), (b) NPI (X2 = 17.72, p = .001), (c) the Cohen-Mansfield agitation scale (X2 = 11.45, p = .003), (d) Burden Interview (X2 = 9.19, p = .01), (e) Memory and Behavior Problems Checklist (frequency subscale) (X2 = 11.09, p = .004), (f) STAI-S (X2 = 14.72, p = .001), and (g) Beck's Depression Inventory (X2 = 9.38, p = .009). These results and their implications are discussed extensively.

  本文旨在介绍西班牙一家私人基金会（“Fundació la Caixa”）赞助的试点项目的结果，以展示音乐疗法的一些应用，并更系统地评估其对早期至中期阿尔茨海默氏病及相关疾病（ADRD）患者及其家庭护理人员的影响。该项目的对象是来自巴塞罗那郊区农村地区的14名阿尔茨海默氏病疑似患者（5名女性和9名男性）和14名家庭护理人员（9名女性和5名男性）。他们的年龄在70至80岁之间。在项目开始前，一位专门研究老年病的神经心理学家对参与者进行了一系列标准化测试。在项目结束前两天和两个月后，为了进行后续跟踪，再次进行了相同的测试。满意度问卷的结果表明，护理人员认为患者的社交和情感方面有所改善，统计测试表明以下测试的测试前后的得分存在显著差异：（a）痴呆量表（X2 = 12.29，p = .002），（b）NPI（X2 = 17.72，p = .001），（c）科恩-曼斯菲尔德躁动量表（X2 = 11.45，p = .003），（d）负担访谈（X2 = 9.19，p = .01），（e）记忆和行为问题清单（频率分量表）（X2 = 11.09，p