甲氧基(2-氧代乙氧基)-乙醛 | 34786-50-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 甲氧基(2-氧代乙氧基)-乙醛
• 英文名称: 2-methoxy-2-(2-oxoethoxy)acetaldehyde
• 英文别名: D'-Methoxy-diglykolaldehyd；Acetaldehyde, methoxy(2-oxoethoxy)-, (S)-
• CAS: 34786-50-0
• 化学式: C₅H₈O₄
• 分子量: 132.116
• InChiKey: CUOMYDZNJOUCKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲氧基(2-氧代乙氧基)-乙醛 在 borohydride 作用下， 生成 (R)-2-methoxy-2,2'-oxy-bis-ethanol
  参考文献：
  名称：

  Fluorination of acetylated glycals

  摘要：

  DOI：

  10.1016/s0040-4039(01)90830-5
• 作为产物：
  描述：

  甲基-L-吡喃阿拉伯糖苷 在 periodate 作用下， 生成 甲氧基(2-氧代乙氧基)-乙醛
  参考文献：
  名称：

  Fluorination of acetylated glycals

  摘要：

  DOI：

  10.1016/s0040-4039(01)90830-5

文献信息

• Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones
  作者：Rachel J. Errington、Maria Sadiq、Laura Cosentino、Marie Wiltshire、Omair Sadiq、Marcella Sini、Enric Lizano、Maria D. Pujol、Goreti R. Morais、Klaus Pors

  DOI：10.1016/j.bmcl.2018.03.040

  日期：2018.5

  Structural features from the anticancer prodrug nemorubicin (MMDX) and the DNA-binding molecule DRAQ5(TM) were used to prepare anthraquinone-based compounds, which were assessed for their potential to interrogate cytochrome P450 (CYP) functional activity and localisation. 1,4-disubstituted anthraquinone 8 was shown to be 5-fold more potent in EJ138 bladder cancer cells after CYP1A2 bioactivation. In contrast, 1,5-bis((2-morpholinoethyl)amino) substituted anthraquinone 10 was not CYP-bioactivated but was shown to be fluorescent and subsequently photo-activated by a light pulse (at a bandwidth 532-587 nm), resulting in punctuated foci accumulation in the cytoplasm. It also showed low toxicity in human osteosarcoma cells. These combined properties provide an interesting prospective approach for opto-tagging single or a sub-population of cells and seeking their location without the need for continuous monitoring. Crown Copyright (C) 2018 Published by Elsevier Ltd. All rights reserved.
• Fluorination of acetylated glycals
  作者：P.W. Kent、J.E.G. Barnett、K.R. Wood

  DOI：10.1016/s0040-4039(01)90830-5

  日期：1963.1