[3-(2-Chlorophenyl)-3-oxo-1-phenylpropyl] pyrrolidine-1-carbodithioate | 1452588-63-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: [3-(2-Chlorophenyl)-3-oxo-1-phenylpropyl] pyrrolidine-1-carbodithioate
• 英文别名: [3-(2-chlorophenyl)-3-oxo-1-phenylpropyl] pyrrolidine-1-carbodithioate
• CAS: 1452588-63-4
• 化学式: C₂₀H₂₀ClNOS₂
• 分子量: 389.97
• InChiKey: BHSKXAAXWABAJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 二硫化碳 、 邻氯苯乙酮 、 苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以85%的产率得到[3-(2-Chlorophenyl)-3-oxo-1-phenylpropyl] pyrrolidine-1-carbodithioate
  参考文献：
  名称：

  An efficient four-component synthesis of dithiocarbamate derivatives

  摘要：

  An environmentally benign, one-pot, four-component synthesis of chemically and pharmaceutically interesting dithiocarbamate derivatives is reported. The one-pot reaction of various aromatic aldehydes, ketones, aliphatic amines, and carbon disulfide, in the presence of potassium hydroxide in urea-choline chloride deep eutectic solvent or ethanol, leads to the corresponding dithiocarbamates in good to excellent yields. This method provides a convenient and time-saving strategy, with a simple work-up procedure. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.124

文献信息

• An efficient four-component synthesis of dithiocarbamate derivatives
  作者：Najmedin Azizi、Meysam Khajeh、Morteza Hasani、Sahar Dezfooli

  DOI：10.1016/j.tetlet.2013.07.124

  日期：2013.9

  An environmentally benign, one-pot, four-component synthesis of chemically and pharmaceutically interesting dithiocarbamate derivatives is reported. The one-pot reaction of various aromatic aldehydes, ketones, aliphatic amines, and carbon disulfide, in the presence of potassium hydroxide in urea-choline chloride deep eutectic solvent or ethanol, leads to the corresponding dithiocarbamates in good to excellent yields. This method provides a convenient and time-saving strategy, with a simple work-up procedure. (c) 2013 Elsevier Ltd. All rights reserved.