甲氯灭酸钠 | 6385-02-0

• 物质功能分类: 原料药 - 解热镇痛药 - 非甾抗炎药
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 甲氯灭酸钠
• 中文别名: 甲氯芬那酸钠；2-[(2,6-二氯-3-甲基苯基)氨基]-苯甲酸钠盐
• 英文名称: 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate
• CAS: 6385-02-0
• 化学式: C14H11Cl2NNaO2
• 分子量: 319.1
• InChiKey: MFQMZIAYWCPXGM-UHFFFAOYSA-N

物化性质

• 熔点：
  287-291 °C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  4.36
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• WGK Germany：
  3
• 海关编码：
  2922499990
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

制备方法与用途

生物活性

Meclofenamate Sodium 是一种双 COX-1/COX-2 抑制剂，其 IC50 分别为40 nM 和50 nM。这种化合物用于治疗关节和肌肉疼痛、关节炎以及痛经。此外，它还是一种非选择性间隙连接阻断剂，并且是脂肪质量和肥胖相关（FTO）酶的高选择性抑制剂。

靶点

Target	Value
COX-1	40 nM
COX-2	50 nM

文献信息

• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• COMPOSITIONS AND PREPARATION METHODS OF LOW MELTING IONIC SALTS OF POORLY-WATER SOLUBLE DRUGS
  申请人：MW ENCAP LIMITED

  公开号：US20160151503A1

  公开（公告）日：2016-06-02

  The disclosure relates generally to ionic salts, particularly low-melting ionic salts such as ionic liquids, of poorly-water soluble drugs. The disclosure further relates to methods of preparing the ionic salts of poorly-water soluble drugs, lipid formulations comprising them and their use in drug delivery.

  本发明涉及离子盐，特别是低熔点的离子盐，例如离子液体，用于难溶于水的药物。本发明还涉及制备难溶于水的药物的离子盐的方法，包含它们的脂质配方以及它们在药物输送中的使用。
• Esters and amides of substituted phenyl and pyridyl amino carboxylates
  申请人：FGN, INC.

  公开号：EP0485171A2

  公开（公告）日：1992-05-13

  Esters and amides of substituted phenyl and pyridyl amino carboxylates having the formula where Y is CH or N ; R1 is one or more substituents independently chosen from lower alkyl, lower haloalkyl, halo, alkoxy or benzyloxy ; Q is the deprotonated residue of a polymeric or macromolecular structure having a molecular weight of at least 1000 containing at least primary and/or secondary amino groups and/or hydroxy groups ; and n is an integer of at least 2 are useful in the treatment of colonic polyps.

  式中的取代苯基和吡啶基氨基羧酸酯和酰胺 其中 Y 是 CH 或 N ； R1 是一个或多个取代基，独立地选自低级烷基、低级卤代烷基、卤代、烷氧基或苄氧基； Q 是分子量至少为 1000 的聚合物或大分子结构的去质子化残基，至少含有伯氨基和/或仲氨基和/或羟基；以及 n 为至少 2 的整数，可用于治疗结肠息肉。
• NOVEL METHODS FOR RAPID DRUG SUSCEPTIBILITY TESTING AND DRUG SCREENS FOR GROWING AND NON-GROWING CELLS OF PROKARYOTIC AND EUKARYOTIC ORIGIN
  申请人：Zhang, Ying

  公开号：EP3321371A1

  公开（公告）日：2018-05-16

  The presently disclosed subject matter provides methods, compositions, and kits for extremely rapid assessment of drug susceptibility of growing as well as non-growing cells of prokaryotic and also eukaryotic origins, without the need for organism growth, which is in contrast to the current growth-dependent methods.This growth-independent new methodology achieves extremely rapid drug susceptibility testing results previously not possible. Methods for rapidly identifying compounds with inhibitory activity against both growing and non-growing cells in real-time continuous manner with previously unachievable efficiency in drug screens using the novel methodology are also provided. Cell cultures are incubated with a drug or test agent and with a staining mixture containing a first fluorescent dye indicative the emission of which is indicative of live cells (e.g. SYBR Green I) and a second fluorescent dye indicative emitting a different color, the emission of which is indicative of dead cells (e.g. Propidium iodide). The ratio of the intensities of the emitted fluorescence of the dyes is indicative of the percentage live and dead cells in the culture.

  与目前依赖生长的方法相比，本公开的主题提供了无需生物体生长即可对原核和真核的生长和非生长细胞的药物敏感性进行极快速评估的方法、组合物和试剂盒，这种不依赖生长的新方法实现了以前无法实现的极快速药物敏感性测试结果。此外，还提供了实时连续地快速鉴定对生长细胞和非生长细胞具有抑制活性的化合物的方法，这种方法在使用新方法进行药物筛选时具有以前无法实现的效率。细胞培养物与药物或测试剂以及染色混合物一起孵育，染色混合物含有第一种荧光染料指示剂，其发射的荧光指示剂可指示活细胞（如 SYBR 绿 I）和第二种发出不同颜色的荧光染料指示剂，其发射的荧光指示剂可指示死细胞（如碘化丙啶）。染料发射荧光强度的比值表示培养液中活细胞和死细胞的百分比。
• BLOOD TREATMENT METHOD AND BLOOD COLLECTION TUBE
  申请人：ARKRAY, Inc.

  公开号：EP3575791A1

  公开（公告）日：2019-12-04

  The method for treating collected blood to be used in a test for rare cells in blood, includes mixing the collected blood with an agent that increases the intracellular concentration of cAMP or an analogous compound thereof. The method for performing a test for rare cells in blood, includes using blood treated using the method according to the present disclosure as a blood sample to be subjected to the test.

  处理采集的血液以用于检测血液中的稀有细胞的方法包括将采集的血液与增加细胞内cAMP或其类似化合物浓度的药剂混合。进行血液中稀有细胞检测的方法，包括使用根据本公开的方法处理过的血液作为要进行检测的血样。