8-Bromo-5-chloro-2-(4-chlorophenyl)imidazo[1,2-c]pyrimidine | 1432446-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8-Bromo-5-chloro-2-(4-chlorophenyl)imidazo[1,2-c]pyrimidine
• 英文别名: 8-bromo-5-chloro-2-(4-chlorophenyl)imidazo[1,2-c]pyrimidine
• CAS: 1432446-12-2
• 化学式: C₁₂H₆BrCl₂N₃
• 分子量: 343.01
• InChiKey: QJMJLAUUGNUJJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-Bromo-5-chloro-2-(4-chlorophenyl)imidazo[1,2-c]pyrimidine 在 三乙烯二胺 、 tris-(dibenzylideneacetone)dipalladium(0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 sodium t-butanolate 作用下， 以 水 、 二甲基亚砜 、 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors

  摘要：

  Chemistry has been developed to access both imidazo[1,2-a]pyrazines and imidazo[1,2-c]pyrimidines. Small structural modifications in both series led to a switch of potency between two kinases involved in mediating cell cycle checkpoint control, CHK1 and MK2.

  DOI：

  10.1016/j.bmcl.2013.03.100
• 作为产物：
  描述：

  8-bromo-2-(4-chlorophenyl)-6H-imidazo[1,2-c]pyrimidin-5-one 在 N,N-二异丙基乙胺 、 三氯氧磷 作用下， 生成 8-Bromo-5-chloro-2-(4-chlorophenyl)imidazo[1,2-c]pyrimidine
  参考文献：
  名称：

  Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors

  摘要：

  Chemistry has been developed to access both imidazo[1,2-a]pyrazines and imidazo[1,2-c]pyrimidines. Small structural modifications in both series led to a switch of potency between two kinases involved in mediating cell cycle checkpoint control, CHK1 and MK2.

  DOI：

  10.1016/j.bmcl.2013.03.100

文献信息

• Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors
  作者：Zhaoyang Meng、Jeffrey P. Ciavarri、Andrew McRiner、Yinyan Zhao、Lianyun Zhao、Panduranga Adulla Reddy、Xingmin Zhang、Thierry O. Fischmann、Charles Whitehurst、M. Arshad Siddiqui

  DOI：10.1016/j.bmcl.2013.03.100

  日期：2013.5

  Chemistry has been developed to access both imidazo[1,2-a]pyrazines and imidazo[1,2-c]pyrimidines. Small structural modifications in both series led to a switch of potency between two kinases involved in mediating cell cycle checkpoint control, CHK1 and MK2.