[(2R,3R,4S,5R,6R)-1,5-bis[[tert-butyl(dimethyl)silyl]oxy]-2,4-dimethyl-6-[(4S,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]heptan-3-yl]oxy-tert-butyl-dimethylsilane | 1383121-94-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4S,5R,6R)-1,5-bis[[tert-butyl(dimethyl)silyl]oxy]-2,4-dimethyl-6-[(4S,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]heptan-3-yl]oxy-tert-butyl-dimethylsilane
• CAS: 1383121-94-5
• 化学式: C₃₄H₇₄O₅Si₃
• 分子量: 647.215
• InChiKey: HMVLTMHAOBXMSM-SVAWKBHESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.48
• 重原子数：
  42
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (3S,4S,5R,6R,7S,8R,9R)-6,8,10-tris((tert-butyldimethylsilyl)oxy)-3,5,7,9-tetramethyldec-1-en-4-ol 在 4-甲基苯磺酸吡啶 、 臭氧 作用下， 以 甲醇 、 二氯甲烷 、 丙酮 为溶剂， 生成 [(2R,3R,4S,5R,6R)-1,5-bis[[tert-butyl(dimethyl)silyl]oxy]-2,4-dimethyl-6-[(4S,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]heptan-3-yl]oxy-tert-butyl-dimethylsilane
  参考文献：
  名称：

  Crotylboron-Based Synthesis of the Polypropionate Units of Chaxamycins A/D, Salinisporamycin, and Rifamycin S

  摘要：

  Syntheses of the C(15)-C(27) fragments of chaxamycins A/D, rifamycin S, and the C(12)-C(24) fragment of salinisporamycin have been accomplished in 10 steps from commercially available starting materials. Three crotylboron reagents were utilized to construct the seven contiguous stereocenters in these fragments with excellent stereoselectivity.

  DOI：

  10.1021/jo3008226

文献信息

• Crotylboron-Based Synthesis of the Polypropionate Units of Chaxamycins A/D, Salinisporamycin, and Rifamycin S
  作者：Ming Chen、William R. Roush

  DOI：10.1021/jo3008226

  日期：2013.1.4

  Syntheses of the C(15)-C(27) fragments of chaxamycins A/D, rifamycin S, and the C(12)-C(24) fragment of salinisporamycin have been accomplished in 10 steps from commercially available starting materials. Three crotylboron reagents were utilized to construct the seven contiguous stereocenters in these fragments with excellent stereoselectivity.