(E,3S,4S,5R,6R,7S,8R,9R)-6,8,10-tris[[tert-butyl(dimethyl)silyl]oxy]-3,5,7,9-tetramethyl-1-tributylstannyldec-1-en-4-ol | 1383121-91-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (E,3S,4S,5R,6R,7S,8R,9R)-6,8,10-tris[[tert-butyl(dimethyl)silyl]oxy]-3,5,7,9-tetramethyl-1-tributylstannyldec-1-en-4-ol
• CAS: 1383121-91-2
• 化学式: C₄₄H₉₆O₄Si₃Sn
• 分子量: 892.21
• InChiKey: REOFUPZGZLGBHO-GEVLIJQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.64
• 重原子数：
  52
• 可旋转键数：
  27
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E,3S,4S,5R,6R,7S,8R,9R)-6,8,10-tris[[tert-butyl(dimethyl)silyl]oxy]-3,5,7,9-tetramethyl-1-tributylstannyldec-1-en-4-ol 在 对甲苯磺酸 作用下， 以 四氢呋喃 为溶剂， 以88%的产率得到(3S,4S,5R,6R,7S,8R,9R)-6,8,10-tris((tert-butyldimethylsilyl)oxy)-3,5,7,9-tetramethyldec-1-en-4-ol
  参考文献：
  名称：

  Crotylboron-Based Synthesis of the Polypropionate Units of Chaxamycins A/D, Salinisporamycin, and Rifamycin S

  摘要：

  Syntheses of the C(15)-C(27) fragments of chaxamycins A/D, rifamycin S, and the C(12)-C(24) fragment of salinisporamycin have been accomplished in 10 steps from commercially available starting materials. Three crotylboron reagents were utilized to construct the seven contiguous stereocenters in these fragments with excellent stereoselectivity.

  DOI：

  10.1021/jo3008226
• 作为产物：
  描述：

  [(E,1R)-1-[bis[(1R,2S,3R,5R)-2,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]boranyl]but-2-enyl]-tributylstannane 、 (2S,3S,4S,5R,6R)-3,5,7-tris[[tert-butyl(dimethyl)silyl]oxy]-2,4,6-trimethylheptanal 以 乙醚 为溶剂， 反应 24.0h， 以87.5%的产率得到
  参考文献：
  名称：

  Crotylboron-Based Synthesis of the Polypropionate Units of Chaxamycins A/D, Salinisporamycin, and Rifamycin S

  摘要：

  Syntheses of the C(15)-C(27) fragments of chaxamycins A/D, rifamycin S, and the C(12)-C(24) fragment of salinisporamycin have been accomplished in 10 steps from commercially available starting materials. Three crotylboron reagents were utilized to construct the seven contiguous stereocenters in these fragments with excellent stereoselectivity.

  DOI：

  10.1021/jo3008226