(3S,4aS,8aR)-3-isopropyl-8a-methyl-4a,5-dihydrobenzo[e][1,2,4]trioxin-6(8aH)-one | 1393526-75-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,4aS,8aR)-3-isopropyl-8a-methyl-4a,5-dihydrobenzo[e][1,2,4]trioxin-6(8aH)-one
• 英文别名: (3S,4aS,8aR)-8a-methyl-3-propan-2-yl-4a,5-dihydro-1,2,4-benzotrioxin-6-one
• CAS: 1393526-75-4
• 化学式: C₁₁H₁₆O₄
• 分子量: 212.246
• InChiKey: JEXCMJVZZCFNHY-GARJFASQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3S,4aS,8aR)-3-isopropyl-8a-methyl-4a,5-dihydrobenzo[e][1,2,4]trioxin-6(8aH)-one 在 溴 、 三乙胺 作用下， 以 四氯化碳 为溶剂， 反应 0.5h， 以75%的产率得到7-bromo-3-isopropyl-8a-methyl-4a,5-dihydrobenzo[e][1,2,4]trioxin-6(8aH)-one
  参考文献：
  名称：

  An Asymmetric Synthesis of 1,2,4-Trioxane Anticancer Agents via Desymmetrization of Peroxyquinols through a Brønsted Acid Catalysis Cascade

  摘要：

  The desymmetrization of p-peroxyquinols using a Bronsted acid-catalyzed acetalization/oxa-Michael cascade was achieved in high yields and selectivities for a variety of aliphatic and aryl aldehydes. Mechanistic studies, suggest that the reaction proceeds through a dynamic kinetic resolution of the peroxy hemiacetal intermediate. The resulting 1,2,4-trioxane products were derivatized and show potent cancer cell-growth inhibition.

  DOI：

  10.1021/ja3052427
• 作为产物：
  描述：

  4-((1-hydroxy-2-methylpropyl)peroxy)-4-methylcyclohexa-2,5-dienone 在 (Ra)-12-hydroxy-1,10-bis(2,4,6-triisopropylphenyl)-4,5,6,7-tetrahydrodiindeno[1,3,2]dioxaphosphocine 12-oxide 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 (3S,4aS,8aR)-3-isopropyl-8a-methyl-4a,5-dihydrobenzo[e][1,2,4]trioxin-6(8aH)-one
  参考文献：
  名称：

  An Asymmetric Synthesis of 1,2,4-Trioxane Anticancer Agents via Desymmetrization of Peroxyquinols through a Brønsted Acid Catalysis Cascade

  摘要：

  The desymmetrization of p-peroxyquinols using a Bronsted acid-catalyzed acetalization/oxa-Michael cascade was achieved in high yields and selectivities for a variety of aliphatic and aryl aldehydes. Mechanistic studies, suggest that the reaction proceeds through a dynamic kinetic resolution of the peroxy hemiacetal intermediate. The resulting 1,2,4-trioxane products were derivatized and show potent cancer cell-growth inhibition.

  DOI：

  10.1021/ja3052427

文献信息

• An Asymmetric Synthesis of 1,2,4-Trioxane Anticancer Agents via Desymmetrization of Peroxyquinols through a Brønsted Acid Catalysis Cascade
  作者：David M. Rubush、Michelle A. Morges、Barbara J. Rose、Douglas H. Thamm、Tomislav Rovis

  DOI：10.1021/ja3052427

  日期：2012.8.22

  The desymmetrization of p-peroxyquinols using a Bronsted acid-catalyzed acetalization/oxa-Michael cascade was achieved in high yields and selectivities for a variety of aliphatic and aryl aldehydes. Mechanistic studies, suggest that the reaction proceeds through a dynamic kinetic resolution of the peroxy hemiacetal intermediate. The resulting 1,2,4-trioxane products were derivatized and show potent cancer cell-growth inhibition.