3-(3-Chloro-4-fluorophenyl)-2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-1,3-thiazolidin-4-one | 1404493-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(3-Chloro-4-fluorophenyl)-2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-1,3-thiazolidin-4-one
• 英文别名: 3-(3-chloro-4-fluorophenyl)-2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-1,3-thiazolidin-4-one
• CAS: 1404493-69-1
• 化学式: C₁₉H₁₄ClFN₂OS₂
• 分子量: 404.916
• InChiKey: ISFJHLCRHNMGPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-甲基-2-苯基-5-羟甲基-1H-咪唑 在 溶剂黄146 、 2-碘酰基苯甲酸 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 反应 0.5h， 生成 3-(3-Chloro-4-fluorophenyl)-2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents

  摘要：

  A new series of 3-aryl-2-(2-aryl/benzyl-4-methylthiazole-5-yl)thiazolidin-4-one was synthesized by condensation of 2-aryl/benzyl-4-methylthiazole-5-carbaldehyde, aromatic amines and thioglycolic acid in toluene. All the synthesized compounds are characterized by IR, NMR and elemental or mass analysis. Sixteen out of the newly synthesized compounds were screened for in vivo anti-inflammatory activity using carrageenan-induced rat paw edema method. Some of the synthesized compounds exhibited good anti-inflammatory activity compared with indomethacin. The synthesized compounds were also evaluated for their in vitro antimicrobial activity. Some of the compounds showed mild antibacterial activity while most of the compounds showed good antifungal activity. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.073