1-(6-Methoxy-2-phenanthren-9-ylquinolin-4-yl)pyrrolidin-2-one | 1407592-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(6-Methoxy-2-phenanthren-9-ylquinolin-4-yl)pyrrolidin-2-one
• 英文别名: 1-(6-methoxy-2-phenanthren-9-ylquinolin-4-yl)pyrrolidin-2-one
• CAS: 1407592-93-1
• 化学式: C₂₈H₂₂N₂O₂
• 分子量: 418.495
• InChiKey: DHTPFQIQGZEGJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-[(2S,4S)-6-methoxy-2-phenanthren-9-yl-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以91%的产率得到1-(6-Methoxy-2-phenanthren-9-ylquinolin-4-yl)pyrrolidin-2-one
  参考文献：
  名称：

  Synthesis of quinoline derivatives for fluorescent imaging certain bacteria

  摘要：

  Highly fluorescent quinoline derivatives were synthesized using Sc(OTf)(3) catalyzed imino Diels-Alder reaction. Both the aromatic and their analogous tetradehydroquinoline derivatives were explored for the detection of bacteria using fluorescent imaging studies. Surprisingly the aromatic quinoline derivatives show a remarkable fluorescent response that can be useful in the detection of both gram positive and gram negative bacteria even at a concentration in the range of 0.078 mM. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.039

文献信息

• Synthesis of quinoline derivatives for fluorescent imaging certain bacteria
  作者：Ramu Dhanapal、Paramasivan T. Perumal、Munusamy Damodiran、Chandrasekaran Ramprasath、Narayanasamy Mathivanan

  DOI：10.1016/j.bmcl.2012.08.039

  日期：2012.10

  Highly fluorescent quinoline derivatives were synthesized using Sc(OTf)(3) catalyzed imino Diels-Alder reaction. Both the aromatic and their analogous tetradehydroquinoline derivatives were explored for the detection of bacteria using fluorescent imaging studies. Surprisingly the aromatic quinoline derivatives show a remarkable fluorescent response that can be useful in the detection of both gram positive and gram negative bacteria even at a concentration in the range of 0.078 mM. (c) 2012 Elsevier Ltd. All rights reserved.