3-乙酰基伞形酮基beta-D-吡喃葡萄糖苷 | 20943-16-2

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 3-乙酰基伞形酮基beta-D-吡喃葡萄糖苷
• 中文别名: 3-乙酰基伞形酮基BETA-D-吡喃葡萄糖苷；3-乙酰基-7-[beta-d-葡萄糖氧基]-香豆素
• 英文名称: 3-acetyl-7β-D-glucopyranosyloxy
• 英文别名: A-3582；coumarin；3-Acetyl-7-β-D-glucopyranosyloxy-cumarin；3-acetyl-7-beta-D-glucopyranosyloxycoumarin；3-acetyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
• CAS: 20943-16-2
• 化学式: C₁₇H₁₈O₉
• mdl: MFCD00037378
• 分子量: 366.325
• InChiKey: KYVGMGQCZKBVDT-OWVAZHOYSA-N

物化性质

• 沸点：
  698.5±55.0 °C(Predicted)
• 密度：
  1.569±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.411
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3

文献信息

• METHODS FOR LYSING EUKARYOTIC CELLS
  申请人：Helixbind Inc.

  公开号：EP3696267A1

  公开（公告）日：2020-08-19

  Methods and devices for isolating microbial cells from a sample, extracting eukaryotic DNA from a sample, and identifying the microbial species in the sample are disclosed herein. To be accompanied, when published, by Figure 1 of the drawings.

  本文公开了从样品中分离微生物细胞、从样品中提取真核 DNA 以及鉴定样品中微生物种类的方法和装置。 出版时附图 1。
• Compositions for the detection of intracellular bacterial targets and other intracellular microorganism targets
  申请人：Becton, Dickinson and Company

  公开号：US10472662B2

  公开（公告）日：2019-11-12

  Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent) is present in a dried form. Presented herein are also methods for detecting the presence of an intracellular microorganism target (e.g., an intracellular bacterial target) utilizing such solid supports. Further, presented herein are tablets as well as dry powders comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent), and methods of using such tablets and dry powders to detect the presence of an intracellular microorganism target (e.g., an intracellular bacterial target).

  本文提出的是固体支持物，其上或其中含有干燥形式的由裂解试剂和细胞内微生物目标检测试剂（如细胞内细菌目标检测试剂）组成的组合物。本文还介绍了利用这种固体支持物检测细胞内微生物靶标（如细胞内细菌靶标）存在的方法。此外，本文还介绍了包含裂解试剂和细胞内微生物靶标检测试剂（如细胞内细菌靶标检测试剂）的片剂和干粉，以及使用此类片剂和干粉检测细胞内微生物靶标（如细胞内细菌靶标）存在的方法。
• Integrated fluidic devices and related methods
  申请人：HelixBind, Inc.

  公开号：US10730041B2

  公开（公告）日：2020-08-04

  Fluidic devices and related methods are generally provided. The fluidic devices described herein may be useful, for example, for diagnostic purposes (e.g., detection of the presence of one or more disease causing bacteria in a patient sample). Unlike certain existing fluidic devices for diagnostic purposes, the fluidic devices and methods described herein may be useful for detecting the presence of numerous disease causing bacteria in a patient sample substantially simultaneously (e.g., in parallel). In some embodiments, the fluidic devices and methods described herein provide highly sensitive detection of microbes in relatively large fluidic samples (e.g., between 0.5 mL and about 5 mL), as compared to certain existing fluidic detection (e.g., microfluidic) devices and methods. In an exemplary embodiment, increased detection sensitivity of microbial pathogens present in a patient sample (e.g., blood) is performed by selectively removing human nucleic acid prior to sensitive detection of microbial infection. In some embodiments, the fluidic device allows for the identification of microbial pathogens directly from unprocessed blood without having to conduct blood culturing processes.

  一般提供流体设备和相关方法。例如，本文所述的流体设备可用于诊断目的（如检测患者样本中是否存在一种或多种致病细菌）。与某些现有的用于诊断目的的流体设备不同，本文所述的流体设备和方法可用于基本同时（例如并行）检测患者样本中是否存在多种致病细菌。在某些实施例中，与某些现有的流体检测（如微流体）设备和方法相比，本文所述的流体设备和方法可对相对较大的流体样本（如 0.5 mL 到约 5 mL）中的微生物进行高灵敏度检测。在一个示例性实施例中，通过在灵敏检测微生物感染之前选择性地去除人类核酸，提高了对患者样本（如血液）中微生物病原体的检测灵敏度。在某些实施例中，流体设备可直接从未经处理的血液中鉴定微生物病原体，而无需进行血液培养过程。
• METHODS AND DEVICES FOR DETECTING AND IDENTIFYING MICROORGANISMS
  申请人：Helixbind Inc.

  公开号：EP3194626A1

  公开（公告）日：2017-07-26
• INTEGRATED FLUIDIC DEVICES AND RELATED METHODS
  申请人：Helixbind, Inc.

  公开号：EP3429751A1

  公开（公告）日：2019-01-23