3-(Chloromethyl)-2-hydroxy-5-nonylbenzaldehyde | 919109-48-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(Chloromethyl)-2-hydroxy-5-nonylbenzaldehyde
• 英文别名: 3-(chloromethyl)-2-hydroxy-5-nonylbenzaldehyde
• CAS: 919109-48-1
• 化学式: C₁₇H₂₅ClO₂
• 分子量: 296.837
• InChiKey: ZSXWJHGAOQGIIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 5-壬基水杨醛 在 盐酸 、 硫酸 、 水 作用下， 反应 240.0h， 以50%的产率得到3-(Chloromethyl)-2-hydroxy-5-nonylbenzaldehyde
  参考文献：
  名称：

  The one-pot halomethylation of 5-substituted salicylaldehydes as convenient precursors for the preparation of heteroditopic ligands for the binding of metal salts

  摘要：

  The one-pot bromo- and chloro-methylation of various 5-substituted salicylaldehydes with paraformaldehyde and hydrobromic or hydrochloric acid has been achieved. This approach establishes a convenient and flexible method to attach functional arms to salicylaidehydes for further applications in organic and coordination chemistry. Examples are described using 3-bromomethyl-5-t-butylsalicylaldehyde in the synthesis of piperazine-containing heteroditopic ligands as receptors for metal salts. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.149

文献信息

• The one-pot halomethylation of 5-substituted salicylaldehydes as convenient precursors for the preparation of heteroditopic ligands for the binding of metal salts
  作者：Qiang Wang、Claire Wilson、Alexander J. Blake、Simon R. Collinson、Peter A. Tasker、Martin Schröder

  DOI：10.1016/j.tetlet.2006.09.149

  日期：2006.12

  The one-pot bromo- and chloro-methylation of various 5-substituted salicylaldehydes with paraformaldehyde and hydrobromic or hydrochloric acid has been achieved. This approach establishes a convenient and flexible method to attach functional arms to salicylaidehydes for further applications in organic and coordination chemistry. Examples are described using 3-bromomethyl-5-t-butylsalicylaldehyde in the synthesis of piperazine-containing heteroditopic ligands as receptors for metal salts. (c) 2006 Elsevier Ltd. All rights reserved.