2-[[4-[3-[4-[(2-Aminophenyl)sulfanylmethyl]phenyl]phenyl]phenyl]methylsulfanyl]aniline | 919285-27-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[4-[3-[4-[(2-Aminophenyl)sulfanylmethyl]phenyl]phenyl]phenyl]methylsulfanyl]aniline
• 英文别名: 2-[[4-[3-[4-[(2-aminophenyl)sulfanylmethyl]phenyl]phenyl]phenyl]methylsulfanyl]aniline
• CAS: 919285-27-1
• 化学式: C₃₂H₂₈N₂S₂
• 分子量: 504.72
• InChiKey: RMCBDRLEGZIMHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[[2-[(2-Carbonochloridoylphenoxy)methyl]-4,5-dimethylphenyl]methoxy]benzoyl chloride 、 2-[[4-[3-[4-[(2-Aminophenyl)sulfanylmethyl]phenyl]phenyl]phenyl]methylsulfanyl]aniline 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 6.0h， 以35%的产率得到31,32-Dimethyl-27,36-dioxa-12,51-dithia-19,44-diazanonacyclo[51.2.2.27,10.12,6.013,18.021,26.029,34.037,42.045,50]hexaconta-1(55),2(60),3,5,7(59),8,10(58),13,15,17,21,23,25,29(34),30,32,37,39,41,45,47,49,53,56-tetracosaene-20,43-dione
  参考文献：
  名称：

  Synthesis and study of anti-inflammatory activity of some novel cyclophane amides

  摘要：

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.124
• 作为产物：
  描述：

  1,3-bis[4-(bromomethyl)phenyl]benzene 、 2-氨基苯硫醇 在 氢氧化钾 、 四丁基溴化铵 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 2-[[4-[3-[4-[(2-Aminophenyl)sulfanylmethyl]phenyl]phenyl]phenyl]methylsulfanyl]aniline
  参考文献：
  名称：

  Synthesis and study of anti-inflammatory activity of some novel cyclophane amides

  摘要：

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.124

文献信息

• Synthesis and study of anti-inflammatory activity of some novel cyclophane amides
  作者：Perumal Rajakumar、A. Mohammed Abdul Rasheed、A. Iman Rabia、D. Chamundeeswari

  DOI：10.1016/j.bmcl.2006.08.124

  日期：2006.12

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.