3-吲哚基琥珀酸 | 10184-94-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 3-吲哚基琥珀酸
• 英文名称: (3-Indolyl)bernsteinsaeure
• 英文别名: indole-3-succinic acid；3-indolylsuccinic acid；indol-3-yl-succinic acid；Indol-3-yl-bernsteinsaeure；-bernsteinsaeure；(+/-)-(Indol-3-yl)-bernsteinsaeure；2-(1H-indol-3-yl)butanedioic acid
• CAS: 10184-94-8
• 化学式: C₁₂H₁₁NO₄
• 分子量: 233.224
• InChiKey: HVTXQEBIPXLXDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  90.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-吲哚基琥珀酸 生成 3-吲哚丙酸
  参考文献：
  名称：

  Notes: Convenient Syntheses of 3-Indolesuccinic and 3-Indolepropionic Acids

  摘要：

  DOI：

  10.1021/jo01090a631
• 作为产物：
  描述：

  (3-Indolyl)bernsteinsaeuredinitril 在 sodium hydroxide 作用下， 反应 8.0h， 以90%的产率得到3-吲哚基琥珀酸
  参考文献：
  名称：

  Droste, Holger; Wieland, Theodor, Liebigs Annalen der Chemie, 1987, p. 901 - 910

  摘要：

  DOI：

文献信息

• Synthesis and Structure Activity Relationship of Rigidized Indolyl Pyrrolidine Derivatives as 5-HT6 Receptor Ligands
  作者：Ramakrishna Nirogi、Adireddy Dwarampudi、Venugopalarao Bhatta、Laxman Kota、P.K. Dubey

  DOI：10.14233/ajchem.2013.15443

  日期：——

  A novel series of rigidized indolyl pyrrolidine derivatives have been designed by constraining the tryptamine nitrogen through a and b carbons. All the synthesized derivatives have shown moderate affinities at 5-HT6R when tested in in vitro binding assay. Synthesis, structure activity relationship (SAR), pharmacokinetic profile and in vivo efficacy of a selected compound is the subject matter of this communication.

  一系列新型刚性吲哚基吡咯烷衍生物通过限制色氨酸胺氮原子与a和b碳的结合而设计。所有合成的衍生物在体外结合测定中对5-HT6R表现出中等亲和力。本通讯的主题是选定化合物的合成、结构活性关系（SAR）、药代动力学特征以及体内疗效。
• Use of indole-3-succinic acid as auxin
  申请人：——

  公开号：US20030158043A1

  公开（公告）日：2003-08-21

  Indole-3-succinic acid and its derivatives are used as auxins. They are administered to plants to promote root growth.

  吲哚-3-琥珀酸及其衍生物被用作生长素。它们被施用于植物以促进根系生长。
• Cytochrome P450 monooxygenases
  申请人：——

  公开号：US20030041346A1

  公开（公告）日：2003-02-27

  Cytochrome P450 II dependent monooxygenases and DNA molecules encoding these monooxygenases are provided, which are able to catalyze the biosynthethic conversion of aldoximes to nitrils and the conversion of said nitrils to the corresponding cyanohydrins, which are the presursors of cyanogenic glycosides. Moreover, the invention provides methods for obtaining DNA molecules according to the invention and methods for obtaining transgenic plants resistant to insects, acarids, or nematodes or plants with improved nutritive value.

  本发明提供了依赖于细胞色素P450II的单加氧酶和编码这些单加氧酶的DNA分子，这些单加氧酶能够催化醛肟的生物合成转化为腈和将所述腈转化为相应的氰醇，这些是青霉素糖苷的前体。此外，本发明还提供了根据本发明获得DNA分子的方法和获得对昆虫、螨虫或线虫具有抗性或具有改善营养价值的转基因植物的方法。
• Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
  申请人：G.D. Searle & Co.

  公开号：EP0396124A2

  公开（公告）日：1990-11-07

  Compositions containing certain indole-2-carboxylate compounds and derivatives are described as being therapeutically effective in treatment of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Preferred compounds are of the formula wherein each of R5 and R6 is independently selected from hydrido, bromo, chloro and fluoro, and wherein each of R10 and R12 is independently selected from hydride and lower alkyl, and pharmaceutically-acceptable salts thereof.

  据描述，含有某些吲哚-2-羧酸盐化合物和衍生物的组合物对治疗神经毒性损伤或神经退行性疾病导致的中枢神经系统疾病，特别是缺血性事件导致的中枢神经系统疾病具有治疗效果。优选的化合物如下式所示 其中 R5 和 R6 各自独立地选自氢基、溴基、氯基和氟基，R10 和 R12 各自独立地选自氢基和低级烷基，及其药学上可接受的盐。
• Expression of S-locus specific glycoprotein gene in transgenic plants
  申请人：CIBA-GEIGY AG

  公开号：EP0436467A2

  公开（公告）日：1991-07-10

  The present invention describes the introduction of a S-locus specific glycoprotein gene isolated from one plant strain into another plant strain that does not ordinarily synthesize S-locus specific glycoprotein.

  本发明描述了将从一种植物品系中分离出来的 S-病灶特异性糖蛋白基因导入另一种通常不合成 S-病灶特异性糖蛋白的植物品系中。