1-Methyl-5-methylene-4,5-dihydro-1H-cyclopenta[b]pyrrol-6-one | 143159-33-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methyl-5-methylene-4,5-dihydro-1H-cyclopenta[b]pyrrol-6-one
• 英文别名: 1-Methyl-5-methylidene-4,5-dihydrocyclopenta[b]pyrrol-6(1H)-one；1-methyl-5-methylidene-4H-cyclopenta[b]pyrrol-6-one
• CAS: 143159-33-5
• 化学式: C₉H₉NO
• 分子量: 147.177
• InChiKey: VHORVUNCHWMAEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(1-Methyl-1H-pyrrol-2-yl)-2-trimethylsilanylmethyl-propenone 在 三氯化铁 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以48%的产率得到1-Methyl-5-methylene-4,5-dihydro-1H-cyclopenta[b]pyrrol-6-one
  参考文献：
  名称：

  Synthesis of α-methylenecyclopentanones via silicon directed nazarov reaction of α-trimethylsilymethyl substituted divinyl ketones.

  摘要：

  Reactions of alpha-trimethylsilylmethyl-substituted divinyl ketones with FeCl3 gave alpha-methylenecyclopentanones. Thienyl and N-methylpyrrolyl (alpha-trimethylsilylmethyl)vinyl ketones also underwent cyclization to afford the corresponding alpha-methylenecyclopentanones.

  DOI：

  10.1016/s0040-4039(00)92672-8

文献信息

• Synthesis of α-methylenecyclopentanones via silicon directed nazarov reaction of α-trimethylsilymethyl substituted divinyl ketones.
  作者：Kyung-Tae Kang、Soung Sin Kim、Jae Chul Lee、Jong Sun U.

  DOI：10.1016/s0040-4039(00)92672-8

  日期：1992.6

  Reactions of alpha-trimethylsilylmethyl-substituted divinyl ketones with FeCl3 gave alpha-methylenecyclopentanones. Thienyl and N-methylpyrrolyl (alpha-trimethylsilylmethyl)vinyl ketones also underwent cyclization to afford the corresponding alpha-methylenecyclopentanones.