5-Hydroxy-5-methyl-4-methylidenehexan-3-one | 89546-23-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Hydroxy-5-methyl-4-methylidenehexan-3-one
• 英文别名: 5-hydroxy-5-methyl-4-methylidenehexan-3-one
• CAS: 89546-23-6
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: YHUIVMGYPNYUFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Hydroxy-5-methyl-4-methylidenehexan-3-one 、 2-丙炔-1-醇 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以62%的产率得到4-ethyl-6-methyl-5-methylidenehept-2-yne-1,4,6-triol
  参考文献：
  名称：

  An expeditious, bidirectional synthesis of furofuranones: a new application of Morita–Baylis–Hillman adducts

  摘要：

  A concise, flexible approach of general utility to the furo[3,2-b]furanones frorn readily available Morita Baylis-Hillman adducts is delineated In an expeditious variant of this approach, a four-step cascade process is executed in a one-pot operation to generate the furofuranoid framework containing two quaternary centers (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2009.09.059
• 作为产物：
  描述：

  2-methyl-3-methylidenehexane-2,4-diol 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以93%的产率得到5-Hydroxy-5-methyl-4-methylidenehexan-3-one
  参考文献：
  名称：

  An expeditious, bidirectional synthesis of furofuranones: a new application of Morita–Baylis–Hillman adducts

  摘要：

  A concise, flexible approach of general utility to the furo[3,2-b]furanones frorn readily available Morita Baylis-Hillman adducts is delineated In an expeditious variant of this approach, a four-step cascade process is executed in a one-pot operation to generate the furofuranoid framework containing two quaternary centers (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2009.09.059

文献信息

• An expeditious, bidirectional synthesis of furofuranones: a new application of Morita–Baylis–Hillman adducts
  作者：Goverdhan Mehta、Bilal Ahmad Bhat、T.H. Suresha Kumara

  DOI：10.1016/j.tetlet.2009.09.059

  日期：2009.11

  A concise, flexible approach of general utility to the furo[3,2-b]furanones frorn readily available Morita Baylis-Hillman adducts is delineated In an expeditious variant of this approach, a four-step cascade process is executed in a one-pot operation to generate the furofuranoid framework containing two quaternary centers (C) 2009 Elsevier Ltd All rights reserved