tert-butyl (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butanoate | 1376622-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butanoate
• CAS: 1376622-71-7
• 化学式: C₃₁H₃₉NO₄
• 分子量: 489.655
• InChiKey: IABPWOXMIYHCSM-NDDXJGTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.57
• 重原子数：
  36.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  48.0
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  tert-butyl (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butanoate 在 lithium aluminium tetrahydride 、 乙酸乙酯 作用下， 以 四氢呋喃 为溶剂， 以77%的产率得到(R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol
  参考文献：
  名称：

  Ring-closing iodoamination of homoallylic amines for the synthesis of polysubstituted pyrrolidines: application to the asymmetric synthesis of (−)-codonopsinine

  摘要：

  Ring-closing iodoamination of (E)-configured, N-alpha-methyl-p-methoxybenzyl protected homoallylic amines upon treatment with 12 and NaHCO3 in MeCN occurs with concomitant loss of the N-alpha-methyl-p-methoxybenzyl group to give 3-iodopyrrolidines in >99:1 dr. This transformation was used as one of the key steps in the total asymmetric synthesis of (-)-codonopsinine, which was achieved in seven steps (from commercially available tert-butyl crotonate) in 5% overall yield and >99:1 dr. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.045
• 作为产物：
  描述：

  (R)-N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amine 在 正丁基锂 、 sodium hydride 作用下， 以 四氢呋喃 、 正己烷 、 mineral oil 为溶剂， 反应 26.5h， 生成 tert-butyl (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butanoate
  参考文献：
  名称：

  Ring-closing iodoamination of homoallylic amines for the synthesis of polysubstituted pyrrolidines: application to the asymmetric synthesis of (−)-codonopsinine

  摘要：

  Ring-closing iodoamination of (E)-configured, N-alpha-methyl-p-methoxybenzyl protected homoallylic amines upon treatment with 12 and NaHCO3 in MeCN occurs with concomitant loss of the N-alpha-methyl-p-methoxybenzyl group to give 3-iodopyrrolidines in >99:1 dr. This transformation was used as one of the key steps in the total asymmetric synthesis of (-)-codonopsinine, which was achieved in seven steps (from commercially available tert-butyl crotonate) in 5% overall yield and >99:1 dr. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.045