7-Amino-1-[[4-[4-(aminomethyl)phenyl]phenyl]methyl]-4-methylquinolin-2-one | 1449476-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Amino-1-[[4-[4-(aminomethyl)phenyl]phenyl]methyl]-4-methylquinolin-2-one
• CAS: 1449476-62-3
• 化学式: C₂₄H₂₃N₃O
• 分子量: 369.466
• InChiKey: KJMQFNCMPHJYHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  72.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Amino-1-[[4-[4-(aminomethyl)phenyl]phenyl]methyl]-4-methylquinolin-2-one 以 二甲基亚砜 为溶剂， 反应 0.67h， 生成 2-[2-[Bis(carboxymethyl)amino]ethyl-[2-[[2-[[1-[[4-[4-[[(2-bromoacetyl)amino]methyl]phenyl]phenyl]methyl]-4-methyl-2-oxoquinolin-7-yl]amino]-2-oxoethyl]-(carboxymethyl)amino]ethyl]amino]acetic acid
  参考文献：
  名称：

  New quinolone-based thiol-reactive lanthanide luminescent probes

  摘要：

  Luminescent lanthanide ion complexes are distinguished by unique light emitting properties that enable both highly sensitive detection of lanthanide labels attached to biomolecules and contrast imaging of various micro objects (cells, nanoparticles, etc.). Previously, we synthesized amine-reactive cs124-based luminescent lanthanide chelates with improved brightness and metal retention. Here we report the synthesis of new thiol-reactive derivatives of the same compounds including bromoacetamido-, and maleimido-forms of cs124 and cs124CF(3) fluorophores. Maleimido-compounds displayed exceptional reactivity instantaneously coupling to thiols at physiological conditions at micromolar probes concentrations. Surprisingly, they displayed strong quenching by adjacent maleimido-group, which was completely eliminated after reaction with thiols, thereby enabling their simple detection by monitoring the light emission of the reaction mixture. This reaction can be used for hyper-sensitive determination of biologically important sulphydryl compounds (e.g. glutathione, co-enzyme A, etc.) in time-resolved mode. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotochem.2012.12.008

文献信息

• FLUOROPHORE CHELATED LANTHANIDE LUMINESCENT PROBES WITH IMPROVED QUANTUM EFFICIENCY
  申请人：Rutgers, The State University of New Jersey

  公开号：US20160194690A1

  公开（公告）日：2016-07-07

  The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.

  本发明涉及一种含有荧光物质的新型发光组成物、制备该组成物的合成方法、该组成物的大分子共轭物以及在各种检测方法中使用该组成物的方法。本发明还提供了包含该组成物及其共轭物的试剂盒，用于检测方法。
• US9732378B2
  申请人：——

  公开号：US9732378B2

  公开（公告）日：2017-08-15