4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol | 1252807-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol
• 英文别名: 4-[4-[[8-[3-(difluoromethoxy)phenyl]quinolin-6-yl]methoxy]phenyl]-2-methylbutan-2-ol
• CAS: 1252807-76-3
• 化学式: C₂₈H₂₇F₂NO₃
• 分子量: 463.524
• InChiKey: KDAUXYRYNLBXOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  51.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(4-((8-(3-(difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)butan-2-one 、 甲基锂 在 cerium(III) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol
  参考文献：
  名称：

  The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

  摘要：

  The SAR study of a series of 6-aryloxymethyl-8-aryl substituted quinolines is described. Optimization of the series led to the discovery of compound 26b, a highly potent (IC(50) = 0.6 nM) and selective PDE4D inhibitor with a 75-fold selectivity over the A, B, and C subtypes and over 18,000-fold selectivity against other PDE family members. Rat pharmacokinetics and tissue distribution are also summarized. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.076

文献信息

• The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors
  作者：Renee Aspiotis、Denis Deschênes、Daniel Dubé、Yves Girard、Zheng Huang、France Laliberté、Susana Liu、Robert Papp、Donald W. Nicholson、Robert N. Young

  DOI：10.1016/j.bmcl.2010.07.076

  日期：2010.9

  The SAR study of a series of 6-aryloxymethyl-8-aryl substituted quinolines is described. Optimization of the series led to the discovery of compound 26b, a highly potent (IC(50) = 0.6 nM) and selective PDE4D inhibitor with a 75-fold selectivity over the A, B, and C subtypes and over 18,000-fold selectivity against other PDE family members. Rat pharmacokinetics and tissue distribution are also summarized. (c) 2010 Elsevier Ltd. All rights reserved.