α-iodo-trans-cinnamic acid | 18819-65-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: α-iodo-trans-cinnamic acid
• 英文别名: α-Jod-trans-zimtsaeure；trans-α-Iod-zimtsaeure；(Z)-2-iodo-3-phenylprop-2-enoic acid
• CAS: 18819-65-3
• 化学式: C₉H₇IO₂
• 分子量: 274.058
• InChiKey: DHXBCVZQFYNLRC-VURMDHGXSA-N

物化性质

• 熔点：
  130 °C (decomp)
• 沸点：
  344.3±35.0 °C(Predicted)
• 密度：
  1.907±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-iodo-trans-cinnamic acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 苯丙酮酸
  参考文献：
  名称：

  Bougault, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1916, vol. 163, p. 365

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 碘 作用下， 生成 α-iodo-trans-cinnamic acid
  参考文献：
  名称：

  Significant changes in the serum levels of IL-6, h-HGF, and type IV collagen 7S during the perioperative period of a hepatectomy: Relevance to SIRS

  摘要：

  We analyzed the changes in the serum levels of both interleukin-6 (IL-6), human hepatocyte growth factor (h-HGF), and type IV collagen 7S (7S) during the perioperative period of a hepatectomy and evaluated their relationship with systemic inflammatory response syndrome (SIRS), The study subjects consisted of 40 patients who underwent a hepatectomy, In 14 out of 40 patients, postoperative SIRS(+) was observed, Between the SIRS(+) and SIRS(-) cases, there were significant differences in the preoperative values of prothrombin time, hepaplastin test, cholinesterase, and indocyanine green retention at 15 min (P < 0.01). Compared with the SIRS(-) cases, the IL-6, h-HGF, and 7S of the SIRS(+) cases fluctuated in a higher range and remained significantly higher after postoperative day 1 (P < 0.05), Eight out of 14 SIRS(+) patients had postoperative complications, In the 8 SIRS(+) patients with postoperative complications and in the 4 patients in which the SIRS(+) state lasted 3 days or longer, the 7S levels were significantly higher during the perioperative period (P < 0.05), In the SIRS(+) cases, the postoperative levels of IL-6 and h-HGF, as well as pre- and postoperative levels of 7S, were elevated, We therefore consider these levels to be risk factors for complications during the perioperative period of a hepatectomy.

  DOI：

  10.1007/s005950050612

文献信息

• Protein-tyrosine phosphatase inhibitors and uses thereof
  申请人：——

  公开号：US20040214870A1

  公开（公告）日：2004-10-28

  The present invention is directed to compounds of formula (I), 1 or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.

  本发明涉及式(I)的化合物，或其药用适宜盐或前药，用于选择性抑制蛋白酪氨酸磷酸酶-1B（PTP1B），并且用于治疗由过度表达或改变的蛋白酪氨酸磷酸酶1B引起的疾病。
• INHIBITORS OF STAT3 AND USES THEREOF
  申请人：McMurray John S.

  公开号：US20120035114A1

  公开（公告）日：2012-02-09

  Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to bind to the SH2 domain of STAT3, preventing STAT3 from binding to receptors for interleukin-6 family cytokines, growth factors such as the platelet-derived growth factor, the epidermal growth factor, vascular endothelial growth factor, and other signaling molecules such as leptin. Blocking these interactions prevents STAT3 from being phosphorylated on Tyr705, which is required for the dimerization of STAT3, translocation to the nucleus, binding to STAT3 response elements on promotors, and transcription of genes. In addition to these activities, binding to the SH2 domain of STAT3 breaks up pre-formed dimmers, thereby preventing the transcriptional activity of the inhibitor.

  本发明提供了抑制信号转导与激活转录因子3 (STAT3) 活性的化合物，以及制备和使用这些化合物的方法。这些化合物被设计成结合STAT3的SH2结构域，防止STAT3与白细胞介素6家族细胞因子、血小板源性生长因子、表皮生长因子、血管内皮生长因子等生长因子和瘦素等信号分子的受体结合。阻断这些相互作用可防止STAT3在Tyr705位点磷酸化，这是STAT3二聚化、向细胞核转位、结合启动子上的STAT3响应元件和基因转录所必需的。除了这些作用，结合STAT3的SH2结构域还可以分解已形成的二聚体，从而防止抑制剂的转录活性。
• James, Journal of the Chemical Society, 1913, vol. 103, p. 1370
  作者：James

  DOI：——

  日期：——
• Stoermer; Kirchner, Chemische Berichte, 1920, vol. 53, p. 1299
  作者：Stoermer、Kirchner

  DOI：——

  日期：——
• Ortoleva, Gazzetta Chimica Italiana, 1899, vol. 29 I, p. 506
  作者：Ortoleva

  DOI：——

  日期：——