(S)-benzyl 4-(2-cyclopentyl-5-hydroxy-7,7-dimethyl-3-(4-(trifluoromethyl)benzoyl)-5,6,7,8-tetrahydroquinolin-4-yl)piperidine-1-carboxylate | 1220250-30-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-benzyl 4-(2-cyclopentyl-5-hydroxy-7,7-dimethyl-3-(4-(trifluoromethyl)benzoyl)-5,6,7,8-tetrahydroquinolin-4-yl)piperidine-1-carboxylate
• 英文别名: benzyl 4-[(5S)-2-cyclopentyl-5-hydroxy-7,7-dimethyl-3-[4-(trifluoromethyl)benzoyl]-6,8-dihydro-5H-quinolin-4-yl]piperidine-1-carboxylate
• CAS: 1220250-30-5
• 化学式: C₃₇H₄₁F₃N₂O₄
• 分子量: 634.739
• InChiKey: GODKUPZJCFJNMU-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  46
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (S)-benzyl 4-(2-cyclopentyl-5-hydroxy-7,7-dimethyl-3-(4-(trifluoromethyl)benzoyl)-5,6,7,8-tetrahydroquinolin-4-yl)piperidine-1-carboxylate 在 1% Pd/C 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 16.0h， 以68%的产率得到(S)-(2-cyclopentyl-5-hydroxy-7,7-dimethyl-4-(piperidin-4-yl)-5,6,7,8-tetrahydroquinolin-3-yl)(4-(trifluoromethyl)phenyl)methanone
  参考文献：
  名称：

  Novel tetrahydrochinoline derived CETP inhibitors

  摘要：

  In the course of our efforts to identify orally active cholesteryl ester transfer protein (CETP) inhibitors, we have continued to explore tetrahydrochinoline derivatives. Based on BAY 19-4789 structural modifications led to the discovery of novel cycloalkyl substituted compounds. Thus, example 11b is a highly potent CETP inhibitor both in vitro and in vivo in transgenic mice with favourable pharmacokinetic properties for clinical development. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.071
• 作为产物：
  描述：

  在 硼烷-N,N-二乙基苯胺 、 (1R,2S)-1-氨基-2-茚醇 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 (S)-benzyl 4-(2-cyclopentyl-5-hydroxy-7,7-dimethyl-3-(4-(trifluoromethyl)benzoyl)-5,6,7,8-tetrahydroquinolin-4-yl)piperidine-1-carboxylate
  参考文献：
  名称：

  Novel tetrahydrochinoline derived CETP inhibitors

  摘要：

  In the course of our efforts to identify orally active cholesteryl ester transfer protein (CETP) inhibitors, we have continued to explore tetrahydrochinoline derivatives. Based on BAY 19-4789 structural modifications led to the discovery of novel cycloalkyl substituted compounds. Thus, example 11b is a highly potent CETP inhibitor both in vitro and in vivo in transgenic mice with favourable pharmacokinetic properties for clinical development. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.071

文献信息

• Novel tetrahydrochinoline derived CETP inhibitors
  作者：Carsten Schmeck、Heike Gielen-Haertwig、Alexandros Vakalopoulos、Hilmar Bischoff、Volkhart Li、Gabriele Wirtz、Olaf Weber

  DOI：10.1016/j.bmcl.2010.01.071

  日期：2010.3

  In the course of our efforts to identify orally active cholesteryl ester transfer protein (CETP) inhibitors, we have continued to explore tetrahydrochinoline derivatives. Based on BAY 19-4789 structural modifications led to the discovery of novel cycloalkyl substituted compounds. Thus, example 11b is a highly potent CETP inhibitor both in vitro and in vivo in transgenic mice with favourable pharmacokinetic properties for clinical development. (C) 2010 Elsevier Ltd. All rights reserved.