allyl 6-O-(2-tert-butyl-2-methyl-1,3-benzodioxole-4-carbonyl-α-D-galactopyranoside | 251365-50-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: allyl 6-O-(2-tert-butyl-2-methyl-1,3-benzodioxole-4-carbonyl-α-D-galactopyranoside
• CAS: 251365-50-1
• 化学式: C₂₂H₃₀O₉
• 分子量: 438.475
• InChiKey: LVIIQAUPJLVYKP-ODHGYYFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.39
• 重原子数：
  31.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  123.91
• 氢给体数：
  3.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  2-tert-butyl-2-methyl-1,3-benzodioxole-4-carboxylic acid 在 4-二甲氨基吡啶 、 六氟丙烯 、 二乙胺 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 6.5h， 生成 allyl 6-O-(2-tert-butyl-2-methyl-1,3-benzodioxole-4-carbonyl-α-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of an artificial glycoconjugate polymer carrying P k -antigenic trisaccharide and its potent neutralization activity against Shiga-like toxin

  摘要：

  Fluorescence-labeled glycoconjugate polymers carrying carbohydrate segments of a globotriaosyl ceramide (Gb3) were synthesized and subjected to biological assays using Escherichia coli O-157 strains and Shiga-like toxins (Stx-I and Stx-II). For the fluorescence labeling, a new polymerizable fluorescent monomer with a TBMB carbonyl chromophore (Ex. 325 nm, Em. 410 nm) was designed. A glycosyl monomer of the trisaccharide segment of Gb3 was prepared from p-nitrophenyl beta-lactoside and copolymerized with acrylamide and the fluorescent monomer to prepare a fluorescence-labeled glycoconjugate copolymer carrying [alpha-D-galactopyranosyl-(1-->4)-beta-D-galactopyranosyl]-(1-->4)-beta- D-glucopyranoside. The polymer showed potent neutralization activity against Stx-I and also binding activity onto E. coli O-157 strains.

  DOI：

  10.1016/s0968-0896(99)00129-7