| 942498-03-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 942498-03-5
• 化学式: C₄₂H₇₃NO₁₇Si
• 分子量: 892.124
• InChiKey: GQNGGODOYYHNOJ-RBBFCFQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.97
• 重原子数：
  61.0
• 可旋转键数：
  18.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  221.35
• 氢给体数：
  2.0
• 氢受体数：
  17.0

反应信息

• 作为反应物：
  描述：

  (R)-7-methylamino-1-hepten-4-ol 、 在 sodium tetrahydroborate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以36%的产率得到
  参考文献：
  名称：

  Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4″ positions: Improved antibacterial activities

  摘要：

  The design and synthesis of 16-membered azalides modified at the C-15 and 4 '' positions are described. The compounds we report here are characterized by an arylpropenyl group attached to the C-15 position of macrolactone and a carbamoyl group at the C-4 '' position in a neutral sugar. Introduction of alkylcarbamoyl groups to the C-4 '' position was regioselectively achieved by unique and convenient methods via acyl migration. As a result of optimization at the C-3 and 15 positions, several compounds were found to have potent activity against mef- and erm-resistant bacterial strains. These results suggest that 16-membered azalides could be promising compounds as clinical candidates. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.02.017
• 作为产物：
  描述：

  在 lead(IV) tetraacetate 、 sodium carbonate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 苯 、 乙酸乙酯 为溶剂， 反应 0.75h， 以75 mg的产率得到
  参考文献：
  名称：

  Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4″ positions: Improved antibacterial activities

  摘要：

  The design and synthesis of 16-membered azalides modified at the C-15 and 4 '' positions are described. The compounds we report here are characterized by an arylpropenyl group attached to the C-15 position of macrolactone and a carbamoyl group at the C-4 '' position in a neutral sugar. Introduction of alkylcarbamoyl groups to the C-4 '' position was regioselectively achieved by unique and convenient methods via acyl migration. As a result of optimization at the C-3 and 15 positions, several compounds were found to have potent activity against mef- and erm-resistant bacterial strains. These results suggest that 16-membered azalides could be promising compounds as clinical candidates. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.02.017