Methyl 4-[2-(1,3-dioxolan-2-yl)phenyl]-4-oxobutanoate | 1210050-48-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 4-[2-(1,3-dioxolan-2-yl)phenyl]-4-oxobutanoate
• CAS: 1210050-48-8
• 化学式: C₁₄H₁₆O₅
• 分子量: 264.278
• InChiKey: NPBFVEBHDLFGTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 4-[2-(1,3-dioxolan-2-yl)phenyl]-4-oxobutanoate 在 lithium aluminium tetrahydride 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  非均相手性铑催化剂下的连续流对映选择性加氢酰化

  摘要：

  开发了用于连续流对映选择性加氢酰化的非均相手性 Rh 催化剂。所制备的催化剂表现出优异的活性和对映选择性，以定量产率提供光学活性酮，其 ee 为 99%，且没有 Rh 浸出。该催化剂表现出广泛的底物范围，并且在顺序流动反应中，证明了增值化学品的流动合成。

  DOI：

  10.1002/anie.202313778
• 作为产物：
  描述：

  4-(2-甲基苯基)-4-氧代丁酸甲酯 在 氧气 、 aluminum oxide 、 乙二醇 作用下， 以 甲醇 、 四氯化碳 为溶剂， 反应 36.0h， 以66%的产率得到Methyl 4-[2-(1,3-dioxolan-2-yl)phenyl]-4-oxobutanoate
  参考文献：
  名称：

  Effect of Alkyl Substituents on Photorelease from Butyrophenone Derivatives

  摘要：

  Photolysis of 1a yields 4a in organ-saturated methanol, whereas 1b is photostable. Laser flash photolysis of 1a in acetonitrile shows formation of biradical 2a (lambda(max) = 380 nm, tau = similar to 60 ns), which undergoes intersystem crossing to form Z-3a (lambda(max) = 380 nm, tau = 270 ns) and E-3a (lambda(max) = 380 nm, tau = 300 ms). Z-3a regenerates the starting material, whereas E-3b undergoes intramolecular lactonization to release the alcohol moiety and form 4a. Similar laser flash photolysis of 1b shows formation of biradical 2b (lambda(max) = 340 nm, tau = 1.9 mu s in acetonitrile), which is longer-lived than 2a is. However, 2b only undergoes intersystem crossing to form Z-3b (lambda(max) = 380 nm, tau = 4.3 mu s). Calculations demonstrate that intramolecular pseudo hydrogen bonding between the OH moiety and the radical centered on the isopropyl carbon in 2b and the bulkiness of the isopropyl group prevent the necessary rotation to form E-3b. In comparison, 2a does not form an intramolecular pseudo hydrogen bond between the methylene radical center and the OH group, and as a consequence, it undergoes intersystem crossing to form both E- and Z-3a.

  DOI：

  10.1021/jo9021088

文献信息

• Effect of Alkyl Substituents on Photorelease from Butyrophenone Derivatives
  作者：Sivaramakrishnan Muthukrishnan、Jagadis Sankaranarayanan、Tamara C. S. Pace、Armands Konosonoks、Mariel E. DeMichiei、Michael J. Meese、Cornelia Bohne、Anna D. Gudmundsdottir

  DOI：10.1021/jo9021088

  日期：2010.3.5

  Photolysis of 1a yields 4a in organ-saturated methanol, whereas 1b is photostable. Laser flash photolysis of 1a in acetonitrile shows formation of biradical 2a (lambda(max) = 380 nm, tau = similar to 60 ns), which undergoes intersystem crossing to form Z-3a (lambda(max) = 380 nm, tau = 270 ns) and E-3a (lambda(max) = 380 nm, tau = 300 ms). Z-3a regenerates the starting material, whereas E-3b undergoes intramolecular lactonization to release the alcohol moiety and form 4a. Similar laser flash photolysis of 1b shows formation of biradical 2b (lambda(max) = 340 nm, tau = 1.9 mu s in acetonitrile), which is longer-lived than 2a is. However, 2b only undergoes intersystem crossing to form Z-3b (lambda(max) = 380 nm, tau = 4.3 mu s). Calculations demonstrate that intramolecular pseudo hydrogen bonding between the OH moiety and the radical centered on the isopropyl carbon in 2b and the bulkiness of the isopropyl group prevent the necessary rotation to form E-3b. In comparison, 2a does not form an intramolecular pseudo hydrogen bond between the methylene radical center and the OH group, and as a consequence, it undergoes intersystem crossing to form both E- and Z-3a.
• Continuous‐Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts
  作者：Yuki Saito、Shū Kobayashi

  DOI：10.1002/anie.202313778

  日期：2024.1.2

  Heterogeneous chiral Rh catalysts were developed for continuous-flow enantioselective hydroacylations. The prepared catalysts exhibited excellent activity and enantioselectivity affording optically active ketones in quantitative yields with 99 % ee's without the leaching of Rh. The catalysts exhibited a wide substrate scope and, in sequential-flow reactions, the flow syntheses of value-added chemicals

  开发了用于连续流对映选择性加氢酰化的非均相手性 Rh 催化剂。所制备的催化剂表现出优异的活性和对映选择性，以定量产率提供光学活性酮，其 ee 为 99%，且没有 Rh 浸出。该催化剂表现出广泛的底物范围，并且在顺序流动反应中，证明了增值化学品的流动合成。