7-(2'-hydroxy-1,1':3',1''-terphenyl-5'-yl)-10,10-dimethyl-7,8,9,10,11,12-hexahydrobenzo[c]acridin-8-one | 1217079-87-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(2'-hydroxy-1,1':3',1''-terphenyl-5'-yl)-10,10-dimethyl-7,8,9,10,11,12-hexahydrobenzo[c]acridin-8-one
• 英文别名: 7-(4-hydroxy-3,5-diphenylphenyl)-10,10-dimethyl-7,9,11,12-tetrahydronaphtho[1,2-b]quinolin-8-one
• CAS: 1217079-87-2
• 化学式: C₃₇H₃₁NO₂
• 分子量: 521.659
• InChiKey: WHYSJDPUDRZSJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  40
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2'-羟基-1,1':3',1''-三联苯-5'-甲醛 、 1-萘胺 、 5,5-二甲基-1,3-环己二酮 以 乙醇 为溶剂， 反应 5.25h， 以76%的产率得到7-(2'-hydroxy-1,1':3',1''-terphenyl-5'-yl)-10,10-dimethyl-7,8,9,10,11,12-hexahydrobenzo[c]acridin-8-one
  参考文献：
  名称：

  Reaction of 2′-hydroxy-1,1′: 3′,1″-terphenyl-5′-carbaldehyde with naphthalen-1-amine, quinolin-8-amine, and 1,3-diketones

  摘要：

  Condensation of 2'-hydroxy-1,1': 3',1aEuro(3)-terphenyl-5'-carbaldehyde with naphthalen-1-amine and cyclohexane-1,3-dione, methyl 2,2-dimethyl-4,6-dioxocyclohexane-1-carboxylate, or dimedone gave the corresponding 7-(2'-hydroxy-1,1': 3',1aEuro(3)-terphenyl-5'-yl)-7,8,9,10,11,12-hexahydro-12H-benzo[c]acridin-8-ones. The reaction of 2'-hydroxy-1,1': 3',1aEuro(3)-terphenyl-5'-carbaldehyde with naphthalen-1-amine and indan-1,3-dione produced 7-(2'-hydroxy-1,1': 3',1aEuro(3)-terphenyl-5'-yl)-8H-benzo[h]indeno[1,2-b]quinolin-8-one. 7-(2'-Hydroxy-1,1': 3',1aEuro(3)-terphenyl-5'-yl)-7,8,9,10,11,12-hexahydrobenzo[b][1,10]phenanthrolin-8-ones were obtained by three-component condensation of 2'-hydroxy-1,1': 3',1aEuro(3)-terphenyl-5'-carbaldehyde with quinolin-8-amine and cyclohexane-1,3-dione, methyl 2,2-dimethyl-4,6-dioxocyclohexane-1-carboxylate, or dimedone.

  DOI：

  10.1134/s1070428009100133