5-Methoxy-2-pyridin-4-yl-1H-benzoimidazole-4,7-dione | 773892-09-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Methoxy-2-pyridin-4-yl-1H-benzoimidazole-4,7-dione
• 英文别名: 6-methoxy-2-pyridin-4-yl-1H-benzimidazole-4,7-dione
• CAS: 773892-09-4
• 化学式: C₁₃H₉N₃O₃
• 分子量: 255.233
• InChiKey: ONMZXAONUNUDBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(4-pyridyl)-4,7-dimethoxybenzimidazole 在 ammonium hydroxide 、 ammonium cerium(IV) nitrate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 5-Methoxy-2-pyridin-4-yl-1H-benzoimidazole-4,7-dione
  参考文献：
  名称：

  Differential antiproliferative activity of new benzimidazole-4,7-diones

  摘要：

  Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.

  DOI：

  10.1016/j.farmac.2004.04.001

文献信息

• Differential antiproliferative activity of new benzimidazole-4,7-diones
  作者：Laura Garuti、Marinella Roberti、Daniela Pizzirani、Annalisa Pession、Emanuela Leoncini、Valentina Cenci、Silvana Hrelia

  DOI：10.1016/j.farmac.2004.04.001

  日期：2004.8

  Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.