(2R,3R,4R,4aR,10aR)-6,6,8,8-Tetraisopropyl-3,4-dimethoxy-2-phenyl-hexahydro-1,5,7,9-tetraoxa-6,8-disila-benzocyclooctene | 886039-87-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4R,4aR,10aR)-6,6,8,8-Tetraisopropyl-3,4-dimethoxy-2-phenyl-hexahydro-1,5,7,9-tetraoxa-6,8-disila-benzocyclooctene
• CAS: 886039-87-8
• 化学式: C₂₆H₄₆O₆Si₂
• 分子量: 510.819
• InChiKey: RNTKNCPQYNYVTK-SDVOOXDOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.11
• 重原子数：
  34.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  55.38
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (2R,3R,4R,4aR,10aR)-6,6,8,8-Tetraisopropyl-3,4-dimethoxy-2-phenyl-hexahydro-1,5,7,9-tetraoxa-6,8-disila-benzocyclooctene 在 camphor-10-sulfonic acid 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 35.0h， 生成 (2R,4aR,6R,7R,8R,8aS)-7,8-Dimethoxy-2,6-diphenyl-hexahydro-pyrano[3,2-d][1,3]dioxine
  参考文献：
  名称：

  Synthesis and screening of bicyclic carbohydrate-based compounds: A novel type of antivirals

  摘要：

  A small library of bicyclic carbohydrate derivatives was synthesized and screened. A strong and selective activity against cytomegalovirus was found. Structure-activity relationship for this new type of antivirals is discussed. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.048
• 作为产物：
  描述：

  (2R,3S,4R,4aS,10aR)-6,6,8,8-Tetraisopropyl-2-phenyl-hexahydro-1,5,7,9-tetraoxa-6,8-disila-benzocyclooctene-3,4-diol 、 碘甲烷 在 silver(l) oxide 作用下， 以93%的产率得到(2R,3R,4R,4aR,10aR)-6,6,8,8-Tetraisopropyl-3,4-dimethoxy-2-phenyl-hexahydro-1,5,7,9-tetraoxa-6,8-disila-benzocyclooctene
  参考文献：
  名称：

  Synthesis and screening of bicyclic carbohydrate-based compounds: A novel type of antivirals

  摘要：

  A small library of bicyclic carbohydrate derivatives was synthesized and screened. A strong and selective activity against cytomegalovirus was found. Structure-activity relationship for this new type of antivirals is discussed. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.048