| 1314239-85-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1314239-85-4
• 化学式: C₂₄H₂₈O₆
• 分子量: 412.483
• InChiKey: RTKUEYKVNDOBNM-SJSRKZJXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.67
• 重原子数：
  30.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  99.38
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Glucosides with cyclic diarylpolynoid as novel C-aryl glucoside SGLT2 inhibitors

  摘要：

  Novel C-aryl glucoside SGLT2 inhibitors containing cyclic diarylpolynoid motif were designed and synthesized for biological evaluation. Alkylzinc bromides have been efficiently prepared by the direct insertion of zinc metal into alkyl bromides. The organozinc reagents underwent smooth Pd-catalyzed cross-coupling reactions. Subsequent ring closing metathesis using 2nd generation Grubbs catalyst successfully generated novel class of ansa-compounds. These glucosides with cyclic diarylpolynoids demonstrated moderate in vitro inhibitory activity against SGLT2 in this series to date (IC50 = 59.5-103 nM). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.063