3-环戊基-1-羟基丙烷-2-酮 | 1021939-26-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-环戊基-1-羟基丙烷-2-酮
• 英文名称: 3-cyclopentyl-1-hydroxypropan-2-one
• 英文别名: 1-Cyclopentyl-3-hydroxypropan-2-one
• CAS: 1021939-26-3
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: BKZMABMHXVGJHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-环戊基-1-羟基丙烷-2-酮 、 3-(4-溴苯基)丙醛 在 ammonium acetate 、 copper diacetate 作用下， 以 溶剂黄146 为溶剂， 反应 0.67h， 生成
  参考文献：
  名称：

  Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

  摘要：

  This Letter describes a series of potent and selective BRS-3 agonists containing a biarylethylimidazole pharmacophore. Extensive SAR studies were carried out with different aryl substitutions. This work led to the identification of a compound 2-{2-[4-(pyridin-2-yl) phenyl] ethyl}-5-(2,2-dimethylbutyl)-1H-imidazole 9 with excellent binding affinity (IC(50) = 18 nM, hBRS-3) and functional agonist activity (EC(50) = 47 nM, 99% activation). After oral administration, compound 9 had sufficient exposure in diet induced obese mice to demonstrate efficacy in lowering food intake and body weight via BRS-3 activation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.076

文献信息

• Substituted imidazoles as bombesin receptor subtype-3 modulators
  申请人：Dobbelaar Peter H.

  公开号：US20100204236A1

  公开（公告）日：2010-08-12

  Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

  某些新型取代咪唑是人类炸弹肽受体的配体，特别是人类炸弹肽受体亚型-3（BRS-3）的选择性配体。因此，它们可用于治疗、控制或预防对BRS-3调节敏感的疾病和障碍，例如肥胖症和糖尿病。
• RADIATION-SENSITIVE RESIN COMPOSITION AND RESIST PATTERN-FORMING METHOD
  申请人：JSR CORPORATION

  公开号：US20190146340A1

  公开（公告）日：2019-05-16

  A radiation-sensitive resin composition includes a polymer; a radiation-sensitive acid generator; and a solvent. The polymer includes a first structural unit and a second structural unit. The first structural unit includes: a first acid-labile group represented by formula (A); and an oxoacid group protected by the first acid-labile group, or a phenolic hydroxyl group protected by the first acid-labile group. The second structural unit includes: a second acid-labile group other than the first acid-labile group; and an oxoacid group protected by the second acid-labile group, or a phenolic hydroxyl group protected by the second acid-labile group.
• US8183275B2
  申请人：——

  公开号：US8183275B2

  公开（公告）日：2012-05-22
• Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
  作者：Jian Liu、Shuwen He、Tianying Jian、Peter H. Dobbelaar、Iyassu K. Sebhat、Linus S. Lin、Allan Goodman、Cheng Guo、Peter R. Guzzo、Mark Hadden、Alan J. Henderson、Kevin Pattamana、Megan Ruenz、Bruce J Sargent、Brian Swenson、Larry Yet、Constantin Tamvakopoulos、Qianping Peng、Jie Pan、Yanqing Kan、Oksana Palyha、Theresa M. Kelly、Xiao-Ming Guan、Andrew D. Howard、Donald J. Marsh、Joseph M. Metzger、Marc L. Reitman、Matthew J. Wyvratt、Ravi P. Nargund

  DOI：10.1016/j.bmcl.2010.02.076

  日期：2010.4

  This Letter describes a series of potent and selective BRS-3 agonists containing a biarylethylimidazole pharmacophore. Extensive SAR studies were carried out with different aryl substitutions. This work led to the identification of a compound 2-2-[4-(pyridin-2-yl) phenyl] ethyl}-5-(2,2-dimethylbutyl)-1H-imidazole 9 with excellent binding affinity (IC(50) = 18 nM, hBRS-3) and functional agonist activity (EC(50) = 47 nM, 99% activation). After oral administration, compound 9 had sufficient exposure in diet induced obese mice to demonstrate efficacy in lowering food intake and body weight via BRS-3 activation. (C) 2010 Elsevier Ltd. All rights reserved.