Methyl 7-[bis(2-methylsulfonyloxyethyl)amino]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylate | 952153-70-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Methyl 7-[bis(2-methylsulfonyloxyethyl)amino]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylate
• CAS: 952153-70-7
• 化学式: C₂₁H₂₇FN₂O₁₀S₂
• 分子量: 550.583
• InChiKey: FNGNDWXMJQEPNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  36
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  163
• 氢给体数：
  0
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  N-羟基氨基甲酸叔丁酯 、 Methyl 7-[bis(2-methylsulfonyloxyethyl)amino]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylate 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.17h， 以23%的产率得到Tert-butyl 5-(1-cyclopropyl-6-fluoro-8-methoxy-3-methoxycarbonyl-4-oxoquinolin-7-yl)-1,2,5-oxadiazepane-2-carboxylate
  参考文献：
  名称：

  NOVEL COMPOUND HAVING HETEROCYCLIC RING

  摘要：

  公开号：

  EP2009012B1
• 作为产物：
  描述：

  Methyl 7-[bis(2-hydroxyethyl)amino]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylate 、 甲基磺酰氯 在 三乙胺 作用下， 以 乙腈 为溶剂， 以100%的产率得到Methyl 7-[bis(2-methylsulfonyloxyethyl)amino]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylate
  参考文献：
  名称：

  NOVEL COMPOUND HAVING HETEROCYCLIC RING

  摘要：

  公开号：

  EP2009012B1

文献信息

• Novel Compound Having Heterocyclic Ring
  申请人：Suzuki Hideyuki

  公开号：US20090299059A1

  公开（公告）日：2009-12-03

  The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A is optionally substituted or fused and represents (A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms; (A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or (A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom; X 1 is a single bond, —O—, —S—, —NR 2 —, —CO—, —CS—, —CONR 3 —, —NR 4 CO—, —SO 2 NR 5 —, and —NR 6 SO 2 — (wherein R 2 -R 6 are independently hydrogen or lower alkyl), or lower alkylene or lower alkenylene in which one of the preceding groups may intervene; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; R 1 is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent, and an antibacterial agent containing the same.
• US8148362B2
  申请人：——

  公开号：US8148362B2

  公开（公告）日：2012-04-03