N-(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl)acetamide | 1078026-12-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl)acetamide
• 英文别名: N-[4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl]acetamide
• CAS: 1078026-12-6
• 化学式: C₁₅H₁₁IN₂O₂S
• 分子量: 410.235
• InChiKey: NEDYIZYLBCDVDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(4-iodo-phenoxy)-thieno[2,3-c]pyridin-2-ylamine 、 乙酸酐 在 N-乙基二丙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 N-(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl)acetamide
  参考文献：
  名称：

  Discovery of thieno[2,3-c]pyridines as potent COT inhibitors

  摘要：

  Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with improved enzyme potency and cellular activity are disclosed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.037

文献信息

• Discovery of thieno[2,3-c]pyridines as potent COT inhibitors
  作者：Dawn George、Michael Friedman、Hamish Allen、Maria Argiriadi、Claude Barberis、Agnieszka Bischoff、Anca Clabbers、Kevin Cusack、Richard Dixon、Shannon Fix-Stenzel、Thomas Gordon、Bernd Janssen、Yong Jia、Maria Moskey、Christopher Quinn、Jose-Andres Salmeron、Neil Wishart、Kevin Woller、Zhengtian Yu

  DOI：10.1016/j.bmcl.2008.08.037

  日期：2008.9

  Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with improved enzyme potency and cellular activity are disclosed. (C) 2008 Elsevier Ltd. All rights reserved.