N1-(3-Nitro-4-quinolinyl)-1,2-ethanediamine | 1203579-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N1-(3-Nitro-4-quinolinyl)-1,2-ethanediamine
• 英文别名: N'-(3-nitroquinolin-4-yl)ethane-1,2-diamine
• CAS: 1203579-30-9
• 化学式: C11H12N4O2
• mdl: MFCD14702394
• 分子量: 232.24
• InChiKey: SIEYZBMGMYYEQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  96.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS<br/>[FR] COMPOSÉS IMIDAZO[4,5-C] CYCLIQUES SUBSTITUÉS PAR GUANIDINE
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2017040233A1

  公开（公告）日：2017-03-09

  Imidazo[4,5-c] ring compounds, (particularly imidzao[4,5-c]quinolines, 6,7,8,9- tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9- tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituent at the 1- position, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.

  本文披露了咪唑[4,5-c]环化合物（特别是咪唑[4,5-c]喹啉，6,7,8,9-四氢咪唑[4,5-c]喹啉，咪唑[4,5-c]萘啉和6,7,8,9-四氢咪唑[4,5-c]萘啉化合物）在1-位置具有鸟氨酸取代基，以及含有该化合物的制药组合物和制备该化合物的方法。本文还披露了使用该化合物作为免疫反应调节剂的方法，用于诱导动物细胞因子生物合成，并用于治疗包括病毒性和肿瘤性疾病在内的疾病。
• Guanidine substituted imidazo[4,5-c] ring compounds
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10150768B2

  公开（公告）日：2018-12-11

  Imidazo[4,5-c] ring compounds, (particularly imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituent at the 1-position, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.

  本发明公开了在 1 位上具有胍取代基的咪唑并[4,5-c]环化合物（特别是咪唑并[4,5-c]喹啉、6,7,8,9-四氢咪唑并[4,5-c]喹啉、咪唑并[4,5-c]萘啶和 6,7,8,9- 四氢咪唑并[4、5-c]萘啶化合物）、含有这些化合物的药物组合物以及制造这些化合物的方法。还公开了将这些化合物用作免疫反应调节剂、诱导动物体内细胞因子的生物合成以及治疗包括病毒性和肿瘤性疾病在内的疾病的方法。
• GUANIDINE SUBSTITUTED IMIDAZO[4,5-c]RING COMPOUNDS
  申请人：3M Innovative Properties Company

  公开号：EP3344622A1

  公开（公告）日：2018-07-11
• GUANIDINE SUBSTITUTED, FUSED 1H-IMIDAZO[4,5-C]PYRIDINE COMPOUNDS USEFUL IN THE TREATMENT OF VIRAL AND NEOPLASTIC DISEASES
  申请人：3M Innovative Properties Company

  公开号：EP3344622B1

  公开（公告）日：2021-07-07
• GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20180237435A1

  公开（公告）日：2018-08-23

  Imidazo[4,5-c] ring compounds, (particularly imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituent at the 1-position, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.