1-Ethyl-3-(7-pyridin-3-yl-5-pyrimidin-5-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)urea | 1131410-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Ethyl-3-(7-pyridin-3-yl-5-pyrimidin-5-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)urea
• CAS: 1131410-50-8
• 化学式: C₁₈H₁₆N₈O
• 分子量: 360.378
• InChiKey: DZLFFFXZJWAYDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  、 3-吡啶硼酸 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium phosphate 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 生成 1-Ethyl-3-(7-pyridin-3-yl-5-pyrimidin-5-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)urea
  参考文献：
  名称：

  DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity

  摘要：

  The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported. The most potent scaffold was selected for optimization leading to a series with potent Gram-positive antibacterial activity and a low resistance frequency. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.102

文献信息

• Antibacterial Agents
  申请人：Butler Charles Donnell David

  公开号：US20080021059A1

  公开（公告）日：2008-01-24

  The present invention is directed to a new class of triazolopyridine derivatives, to their use as antimicrobials, and to pharmaceuticals containing these compounds.

  本发明涉及一种新型的三唑吡啶衍生物，其用作抗微生物药物，以及含有这些化合物的药物。
• TRIAZOLOPYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1799680A2

  公开（公告）日：2007-06-27
• US7524860B2
  申请人：——

  公开号：US7524860B2

  公开（公告）日：2009-04-28
• [EN] ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTERIENS
  申请人：WARNER LAMBERT CO

  公开号：WO2006038116A2

  公开（公告）日：2006-04-13

  The present invention is directed to a new class of triazolopyridine derivatives, to their use as antimicrobials, and to pharmaceuticals containing these compounds.
• DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
  作者：Stephen P. East、Clara Bantry White、Oliver Barker、Stephanie Barker、James Bennett、David Brown、E. Andrew Boyd、Christopher Brennan、Chandana Chowdhury、Ian Collins、Emmanuelle Convers-Reignier、Brian W. Dymock、Rowena Fletcher、David J. Haydon、Mihaly Gardiner、Stuart Hatcher、Peter Ingram、Paul Lancett、Paul Mortenson、Konstantinos Papadopoulos、Carol Smee、Helena B. Thomaides-Brears、Heather Tye、James Workman、Lloyd G. Czaplewski

  DOI：10.1016/j.bmcl.2008.11.102

  日期：2009.2

  The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported. The most potent scaffold was selected for optimization leading to a series with potent Gram-positive antibacterial activity and a low resistance frequency. (C) 2008 Elsevier Ltd. All rights reserved.